肾上腺皮质发育异常同源蛋白抗体
规格：1mg/1ml
英文名： PTOP
别名： PIP1; Acd; ACD_HUMAN; Adrenocortical dysplasia protein homolog; POT1 and TIN2 organizing protein; POT1 and TIN2-interacting protein; TIN2 interacting protein 1; TINT1; TPP1.
分子量： 58kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PTOP
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Sheep,
肾上腺皮质发育异常同源蛋白抗体细胞定位：细胞核
产品介绍：background: This gene encodes a protein that is involved in telomerefunction. This protein is one of six core proteins in thetelosome/shelterin telomeric complex, which functions to maintaintelomere length and to protect telomere ends. Through itsinteraction with other components, this protein plays a key role inthe assembly and stabilization of this complex, and it mediates theaccess of telomerase to the telomere. Multiple transcript variantsencoding different isoforms have been found for this gene. Thisgene, which is also referred to as TPP1, is distinct from theunrelated TPP1 gene on chromosome 11, which encodestripeptidyl-peptidase I. Function: Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG肾上腺皮质发育异常同源蛋白抗体 repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomer elongation by increasing telomerase processivity. Plays a role in shelterin complex assembly. May play a role in organogenesis. Subunit:肾上腺皮质发育异常同源蛋白抗体 Component of the shelterin complex (telosome) composed ofTERF1, TERF2, TINF2, TERF2IP ACD and POT1. Forms heterodimers withPOT1. Identified in a complex with POT1 and single-strandedtelomeric DNA. Interacts with STN1/OBFC1 and TINF2. Subcellular Location: Nucleus. Chromosome, telomere. Database links: UniProtKB/Swiss-Prot: Q96AP0.3 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
肾上腺皮质发育异常同源蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 细胞周期蛋白 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid