着丝点关联蛋白1抗体
规格：1mg/1ml
英文名： KNTC1
别名： HsROD; Kinetochore associated 1; KNTC1; ROD; Rough Deal homolog, centromere/kinetochore protein; KNTC1_HUMAN.
分子量： 251kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human KNTC1/Ki
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse, Sheep,
细胞定位：细胞核 细胞浆
着丝点关联蛋白1抗体产品介绍：background: The kinetochore is the protein structure in eukaryotes which assembles on the centromere and links the chromosome to microtubule polymers from the mitotic spindle during mitosis and meiosis. The kinetochore contains two regions: an inner kinetochore, which is tightly associated with the centromere DNA; and an outer kinetochore, which interacts with microtubules. Even the simplest kinetochores consist of more than 45 different proteins, many of which are conserved throughout eukaryote species. Function: Essential component of the mitotic checkpoint, whichprevents cells from prematurely exiting mitosis. Required for theassembly of the dynein-dynactin and MAD1-MAD2 complexes ontokinetochores. Subunit: Interacts with ZW10. This interaction is required forstable association with the kinetochore. Component of the RZZcomplex composed of KNTC1/ROD, ZW10 and ZWILCH. Subcellular Location: Cytoplasm. Nucleus. Chromosome,着丝点关联蛋白1抗体 centromere,kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Dynamic patternof localization during the cell cycle. At interphase, uniformlydistributed throughout the cytoplasm and nucleus. By prophase anduntil late stages of prometaphase, a fraction of the total pool isconcentrated at kinetochores. By metaphase, detected atkinetochores, along spindle fibers and most prominently at thepoles. By late anaphase着丝点关联蛋白1抗体 until the end of telophase, no longerdetectable on kinetochores or along spindle fibers, but stillpresent at the spindle poles. Tissue Specificity: High expression in testis. Database links: UniProtKB/Swiss-Prot: P50748.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
着丝点关联蛋白1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 细胞周期蛋白 细胞分化 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit