肌球蛋白相互作用G蛋白交换因子抗体
规格：1mg/1ml
英文名： MyoGEF
别名： Myosin interacting guanine nucleotide exchange factor; PH domain containing family G member 6; Pleckstrin homology domain containing family G (with RhoGef domain) member 6; Pleckstrin homology domain-
分子量： 89kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MyoGEF
交叉反应：Human, Mouse, Rat, Dog, Horse, Rabbit,
细胞定位：细胞浆 细胞膜
肌球蛋白相互作用G蛋白交换因子抗体产品介绍：background: MyoGEF functions as a guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. It activates RHOG but not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving MyoGEF, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis. Function: Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. Also activates RHOG. Does not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving PLEKHG6, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation肌球蛋白相互作用G蛋白交换因子抗体 of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis. Subunit: Interacts with MYH10. Interacts with ELMO1 and EZR (in an open conformation). Interacts with CSPP1. Subcellular Location: Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Cleavage furrow. Note=During mitosis, localizes to the spindle pole肌球蛋白相互作用G蛋白交换因子抗体, central spindle and cleavage furrow. In epithelial cells, recruited to the apical membrane by EZR. Tissue Specificity: Highest expression in the placenta. Low levels in small intestine, lung, liver, kidney, thymus and heart. Similarity: Contains 1 DH (DBL-homology) domain. Contains 1 PH domain. Database links: UniProtKB/Swiss-Prot: Q3KR16.3 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产肌球蛋白相互作用G蛋白交换因子抗体品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 信号转导 细胞周期蛋白 转录调节因子 细胞分化 细胞骨架 细胞外基质 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid
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