细胞分化蛋白SEPT12抗体
规格：1mg/1ml
英文名： 42625
别名： SEPT12; SEPT 12; SEP12_HUMAN; Septin-12; Septin 12; Septin12.
分子量： 41kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SEPT12
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, Zebrafish
细胞定位：细胞浆
细胞分化蛋白SEPT12抗体产品介绍：background: Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis. Function: Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). Subunit: Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By similarity). Interacts with SEPT6 and SEPT11. Forms homodimers. Subcellular Location: Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Cell projection, cilium, flagellum. Note=At interphase, forms a filamentous structure in the cytoplasm. During anaphase, translocates to the central spindle region and to the midbody during cytokinesis. Found in the sperm annulus. Tissue Specificity: Widely expressed. DISEASE: Defects in SEPT12 are the cause of spermatogenic failure 10 (SPGF10) [MIM:614822]. An infertility细胞分化蛋白SEPT12抗体 disorder caused by spermatogenesis defects. It results in decreased sperm motility, concentration, and multiple sperm structural defects. The most prominent feature is a defective sperm annulus, a ring structure that demarcates the midpiece and the principal piece of the sperm tail. Similarity: Belongs to the septin family. Gene ID: 124404 Database links: Entrez Gene: 124404 Human Entrez Gene: 71089细胞分化蛋白SEPT12抗体 Mouse Entrez Gene: 363542 Rat Omim: 611562 Human SwissProt: Q8IYM1 Human SwissProt: Q4V8G5 Rat Unigene: 126780 Human Unigene: 123511 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. SEPTIN(SEPT)家族是细胞骨架蛋白的一种，具有GTPase的活性。经研究发現，SEPT参与细胞核分裂、细胞膜的运输以及构成细胞骨架。
细胞分化蛋白SEPT12抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 细胞周期蛋白 细胞分化 细胞骨架
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid