细胞分化蛋白SEPT14抗体
规格：1mg/1ml
英文名： 42627
别名： SEPT14; SEPT 14; SEP14_HUMAN; Septin-14; Septin 14; Septin14; FLJ44060.
分子量： 50kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SEPT14
交叉反应：Human,
细胞定位：细胞浆
细胞分化蛋白SEPT14抗体产品介绍：background: Septin 14, also known as SEPT14, is a 432 amino acid protein that belongs to the septin family. The highly conserved septin family of GTP-binding cytoskeletal proteins is implicated in membrane transport, apoptosis, cell polarity, cell cycle regulation, cytokinesis and other cellular functions. Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. Septin 14 has a GTPase domain followed by a C-terminal coiled-coil domain characteristic of group II septins. Septin 14 interacted with all septins except those that are members of its phylogenetic cluster, including itself. Septin 14 shares highest identity (67%) with Septin 10. Expressed in testis and more weakly in fetal liver, tonsil and thymus, the Septin 14 protein is not detected in testicular cancer or other normal or cancer cell lines. The Septin 14 gene is conserved in chimpanzee, dog, cow, 细胞分化蛋白SEPT14抗体mouse and rat, and maps to human chromosome 7p11.2. Function: SEPT14 is a filament-forming cytoskeletal GTPase. It may play a role in cytokinesis. Subunit: Septins polymerize into heterooligomeric proteincomplexes that form filaments, and can associate with cellularmembranes, actin filaments and microtubules. GTPase activity isrequired for filament formation (By similarity). Interacts withSEPT9. Subcellular 细胞分化蛋白SEPT14抗体Location: Cytoplasm. Tissue Specificity: Testis-specific. Similarity: Belongs to the septin family. Gene ID: 346288 Database links: Entrez Gene: 346288 Human Omim: 612140 Human SwissProt: Q6ZU15 Human Unigene: 453629 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. SEPTIN(SEPT)家族是细胞骨架蛋白的一种，具有GTPase的活性。经研究发現，SEPT参与细胞的分裂、细胞膜的运输以及构成细胞骨架。
细胞分化蛋白SEPT14抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 细胞周期蛋白 细胞分化 细胞骨架
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid