粘结蛋白SA1抗体
规格：1mg/1ml
英文名： Nuclear protein stromal antigen 1
别名： Cohesin subunit SA 1; Cohesin subunit SA-1; Cohesin Subunit SA1; condensin; Nuclear protein stromal antigen 1; pds 5; SA 1; sa 2; SCC 3 homolog 1; SCC1; Scc3; SCC3 homolog 1; STAG 1; stag1; STAG1_HUMA
分子量： 138kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Nuclear
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：细胞核
粘结蛋白SA1抗体产品介绍：background: This gene is a member of the SCC3 family and is expressed in the nucleus. It encodes a component of cohesin, a multisubunit protein complex that provides sister chromatid cohesion along the length of a chromosome from DNA replication through prophase and prometaphase, after which it is dissociated in preparation for segregation during anaphase. [provided by RefSeq, Jul 2008]. Function: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesion complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Subunit: Interacts directly with RAD21 in cohesin complex. Cohesin complexes are composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein (STAG1, 粘结蛋白SA1抗体STAG2 or STAG3). In cohesin complexes, STAG1 is mutually exclusive with STAG2 and STAG3. Subcellular Location: Nucleus. Chromosome. Chromosome, centromere. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK1, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of cohesin is cleaved, leading to the dissociation of the complex from chromosomes, 粘结蛋白SA1抗体allowing chromosome separation. Post-translational modifications: Phosphorylated by PLK1. The large dissociation of cohesion from chromosome arms during prophase is partly due to its phosphorylation. Similarity: Belongs to the SCC3 family. Contains 1 SCD (stromalin conservative) domain. Database links: UniProtKB/Swiss-Prot: Q8WVM7.3 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
粘结蛋白SA1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 细胞周期蛋白 细胞分化 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid
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