染色体结构维持蛋白4抗体
规格：1mg/1ml
英文名： SMC4
别名： Chromosome associated polypeptide C; hCAP C; XCAP C homolog; CAP C; CAPC; SMC 4; SMC4; SMC4L1; Structural maintenance of chromosomes 4 like 1; SMC4_HUMAN.
分子量： 147kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from hu SMC4
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞核 细胞浆
染色体结构维持蛋白4抗体产品介绍：background: SMC4 is a central component of the condensin complex, which is required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Function: Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Subunit: Forms a heterodimer with SMC2. Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex:染色体结构维持蛋白4抗体 BRRN1/CAPH, CNAP1/CAPD2 and CAPG. Subcellular Location: Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensin's association with 染色体结构维持蛋白4抗体chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase. Tissue Specificity: Widely expressed. Higher expression in testis, colon, thymus. Similarity: Belongs to the SMC family. SMC4 subfamily. Database links: UniProtKB/Swiss-Prot: Q9NTJ3.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
染色体结构维持蛋白4抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 细胞周期蛋白 细胞分化 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid