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中心粒周蛋白抗体

中心粒周蛋白抗体
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  • 产品名称:中心粒周蛋白抗体
  • 产品型号: PCNT
  • 产品展商:单克隆抗体/多克隆抗体
  • 产品文档:无相关文档
简单介绍
中心粒周蛋白抗体应用于IHC、WB、 IF、IP、ELISA等科研实验,按理化性质和生物学功��IgM、IgG、IgA、IgE、IgD五类。按抗体的来源,可将其分为天然抗体和**抗体。中心粒周蛋白抗体生产每个流程都执行严格的检测标准,保证蛋白抗原产品质量,质量稳定,实验效果明显。
产品描述

中心粒周蛋白抗体

规格:1mg/1ml


英文名: PCNT

别名: Centrosome Marker; Ken; Kendrin; KIAA0402; MOPD2; PCN; PCNT 2; PCNT; PCNT B; PCNT1; PCNT2; PCNTB; PCTN2; Pericentrin 1; Pericentrin 1; Pericentrin 2; Pericentrin 380; Pericentrin B; SCKL4.

分子量: 367kDa

储存液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆类型:Polyclonal

亚型:IgG

纯化方法:affinity purified by Protein A

**原:KLH conjugated synthetic peptide derived from human Pericent

交叉反应:Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,

细胞定位:细胞浆

中心粒周蛋白抗体产品介绍:background: The protein encoded by this gene binds to calmodulin and is expressed in the centrosome. It is an integral component of the pericentriolar material (PCM). The protein contains a series of coiled-coil domains and a highly conserved PCM targeting motif called the PACT domain near its C-terminus. The protein interacts with the microtubule nucleation component gamma-tubulin and is likely important to normal functioning of the centrosomes, cytoskeleton, and cell-cycle progression. Mutations in this gene cause Seckel syndrome-4 and microcephalic osteodysplastic primordial dwarfism type II. [provided by RefSeq, Jul 2008]. Function: Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play 中心粒周蛋白抗体an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. Subunit: Interacts with CHD3. Interacts with CHD4; the interaction regulates centrosome integrity (By similarity). Interacts with DISC1 and PCM1. Binds calmodulin. Interacts with CDK5RAP2; the interation is leading to centrosomal localization of PCNT and CDK5RAP2. Interacts with isoform 1 of NEK2. Subcellular Location: Cytoplasm; cytoskeleton; centrosome. Note: Centrosomal at all stages of the cell cycle. Remains associated with centrosomes following microtubule depolymerization. Colocalized with DISC1 at the centrosome Tissue Specificity: Expressed in all tissues tested, including placenta,中心粒周蛋白抗体 liver, kidney and thymus. DISEASE: Defects in PCNT are the cause of microcephalic osteodysplastic primordial dwarfism type 2 (MOPD2) [MIM:210720]; also known as osteodysplastic primordial dwarfism type 2. Adults with this rare inherited condition have an average height of 100 centimeters and a brain size comparable to that of a 3-month-old baby, but are of near-normal intelligence. Database links: UniProtKB/Swiss-Prot: O95613.4 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

中心粒周蛋白抗体产品应用:ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究领域:细胞生物  细胞周期蛋白  细胞分化  

储存条件: Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

来源: Rabbit

外观: Lyophilized or Liquid





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