肽聚糖识别蛋白1抗体
规格：1mg/1ml
英文名： PGRPS
别名： Peptidoglycan recognition protein 1; Peptidoglycan recognition protein; PGLYRP; PGLYRP1; PGRP; PGRP S; PGRP-PEN; PGRP-S; TAG7; TNFSF 3L; TNFSF3L; PGRP1_HUMAN.
分子量： 19kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PGRPS
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞浆 分泌型蛋白
肽聚糖识别蛋白1抗体产品介绍：background: The primary immune recognition is based on structures common among invading pathogens. Bacterial surface molecules, such as lipopolysaccharide (LPS) and peptidoglycan (PGN), are known to elicit immune reactions ranging from cytokine release to fever. Recently, a family of proteins called peptidoglycan recognition protein (PGRP) has been identified in mouse and human that binds to peptidoglycans expressed on Gram-positive bacteria. Peptidoglycan (PGN) is an essential cell wall component of virtually all bacteria and, thus, it is an excellent target for recognition by the eukaryotic innate immune system. The PGRPs (PGRP-L, PGRPS, PGRPIA, and PGRP-I-beta) define a new family of human pattern recognition molecules. PGRP-L is primarily expressed in the liver. Although liver is not considered a primary immune organ, liver participates in host defenses by producing acute phase proteins (by hepatocytes) in response to infections 肽聚糖识别蛋白1抗体and by clearing microorganisms from blood. PGRPS is present in neutrophils and inhibits growth of Gram-positive bacteria and, therefore, may function as a neutrophil antibacterial protein. However, PGRPS may have another, as yet unidentified function because in humans it is expressed in the bone marrow 50–100 times higher than in neutrophils. Function: Pattern receptor that binds to murein peptidoglycans(PGN) of Gram-positive bacteria. Has bactericidal activity towardsGram-positive bacteria. May kill Gram-positive bacteria byinterfering with peptidoglycan biosynthesis. Binds also toGram-negative bacteria, and has bacteriostatic activity towardsGram-negative bacteria. Plays a role in innate immunity. Subunit: Homodimer肽聚糖识别蛋白1抗体; disulfide-linked. Subcellular Location: Secreted. Cytoplasmic granule (Bysimilarity). Tissue Specificity: Highly expressed in bone marrow. Weakexpression found in kidney, liver, small intestine, spleen, thymus,peripheral leukocyte, lung, fetal spleen and neutrophils. Post-translational modifications: N-glycosylated. N-glycosylation is required for bactericidalactivity. Similarity: Belongs to the N-acetylmuramoyl-L-alanine amidase 2family. Gene ID: 8993 Database links: UniProtKB/Swiss-Prot: O75594.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产肽聚糖识别蛋白1抗体品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 微生物学 神经生物学 细胞凋亡 **及病毒 糖蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid
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