β连环蛋白样蛋白1抗体
规格：1mg/1ml
英文名： CTNNBL1
别名： Beta catenin like 1; Beta catenin like protein 1; Beta-catenin-like protein 1; C20orf33; Catenin beta like 1; Chromosome 20 open reading frame 3; CTBL1_HUMAN; CTNNBL 1; Ctnnbl1; NAP; Nuclear associate
分子量： 65kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CTNNBL1/
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞核
β连环蛋白样蛋白1抗体产品介绍：background: The protein encoded by this gene contains an acidic domain, a putative bipartite nuclear localization signal, a nuclear export signal, a leucine-isoleucine zipper, and phosphorylation motifs. In addition, the encoded protein contains Armadillo/beta-catenin-like repeats, which have been implicated in protein-protein interactions. Although the function of this protein has not been determined, the C-terminal portion of the protein has been shown to possess apoptosis-inducing activity. Function: Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis. Subunit: Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8. β连环蛋白样蛋白1抗体Interacts directly with CWC15 and CDC5L in the complex. Interacts with AICDA; the interaction is important for the antibody diversification activity of AICDA. Interacts with PRPF31 (via its NLS). Interacts (via its N-terminal NLS) with KPNA1 and KPNA2. Subcellular Location: Nucleus. Tissue Specificity: Widely expressed with highest levels in skeletal muscle, placenta, heart, spleen, testis and thyroid. Gene ID: 56259 Database links: Entrez Gene: 282421 Cow Entrez Gene: 56259 Human Entrez Gene: 66642 Mouse Entrez Gene: 296320 Rat Omim: 611537 Human SwissProt:β连环蛋白样蛋白1抗体 O62703 Cow SwissProt: Q8WYA6 Human SwissProt: Q9CWL8 Mouse SwissProt: Q4V8K2 Rat Unigene: 472667 Human Unigene: 45193 Mouse Unigene: 98091 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产β连环蛋白样蛋白1抗体品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 染色质和核信号 细胞凋亡
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid