血管紧张素Ⅱ受体相关蛋白抗体
规格：1mg/1ml
英文名： AGTRAP
别名： Angiotensin Ⅱ receptor associated protein; Angiotensin Ⅱ type I receptor associated protein; ATI receptor associated protein; ATRAP; MGC29646; Type 1 angiotensin Ⅱ receptor associated protein; ATRAP_H
分子量： 17kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human AGTRAP
交叉反应：Human, Mouse, Rat, Pig, Horse, Rabbit, Sheep,
细胞定位：细胞浆 细胞膜
血管紧张素Ⅱ受体相关蛋白抗体产品介绍：background: AGTRAP (Angiotensin II receptor-associated protein) interacts with the angiotensin II type 1 receptor and negatively regulates type 1 angiotensin II receptor-mediated signaling, by regulating receptor internalisation as well as mechanisms of receptor desensitization such as phosphorylation. Function: Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity. Subunit: Interacts with GNB2L1/RACK1, 血管紧张素Ⅱ受体相关蛋白抗体and with the C-terminal region of AGTR1. Subcellular Location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein.血管紧张素Ⅱ受体相关蛋白抗体 Note=Present in perinuclear vesicular membranes, Endoplasmic reticulum, Golgi and endocytic vesicles. Tissue Specificity: Ubiquitous but more abundant in kidney, heart, pancreas and thyroid. Gene ID: 57085 Database links: Entrez Gene: 57085 Human Omim: 608729 Human SwissProt: Q6RW13 Human Unigene: 464438 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
血管紧张素Ⅱ受体相关蛋白抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 细胞生物 信号转导 G蛋白偶联受体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid