同源相互作用蛋白激酶4抗体
规格：1mg/1ml
英文名： HIPK4
别名： HIPK 4; HIPK4; HIPK4_HUMAN; Homeodomain interacting protein kinase 4; Homeodomain-interacting protein kinase 4.
分子量： 69kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human HIPK4
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞浆
同源相互作用蛋白激酶4抗体产品介绍：background: The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions in eukaryotes, including cell division, homeostasis and apoptosis. The homeodomain-interacting protein kinases (HIPK1, HIPK2, HIPK3 and HIPK4) comprise a subfamily of kinase proteins that have a conserved protein kinase domain, as well as a separate domain that interacts with homeoproteins. HIPK4 (Homeodomain-interacting protein kinase 4) is a 616 amino acid protein that localizes to the cytoplasm and exists as two isoforms that are produced by alternative splicing events. Like other members of the HIPK family, HIPK4 functions as a protein kinase that catalyzes the ATP-dependent phosphorylation of target proteins and is thought to act as a corepressor of target transcription factors. Function: Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces 同源相互作用蛋白激酶4抗体TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors. Subcellular Location: Cytoplasm (By similarity). Post-translational modifications: Autophosphorylated (By similarity). Similarity: Belongs to the protein kinase superfamily. CMGCSer/Thr protein kinase family. HIPK subfamily. Contains 1 protein kinase domain. Gene ID: 147746 Database links: Entrez Gene:同源相互作用蛋白激酶4抗体 147746 Human Entrez Gene: 233020 Mouse Entrez Gene: 308449 Rat Omim: 611712 Human SwissProt: Q8NE63 Human SwissProt: Q3V016 Mouse SwissProt: Q4V793 Rat Unigene: 79363 Human Unigene: 429716 Mouse Unigene: 41008 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
同源相互作用蛋白激酶4抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 细胞凋亡 细胞周期蛋白 激酶和磷酸酶 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid