富含亮氨酸重复死亡结构域蛋白抗体
规格：1mg/1ml
英文名： LRDD
别名： Leucine rich repeats and death domain containing; Leucine-rich repeats and death domain containing; MGC16925; p53-induced protein with a death domain; PIDD; DKFZp434D229; PIDD_HUMAN.
分子量： 100kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human LRDD/PID
交叉反应：Human, Mouse, Rat,
细胞定位：细胞核 细胞浆
富含亮氨酸重复死亡结构域蛋白抗体产品介绍：background: The death domain (DD) containing protein PIDD is a p53 target gene in an erythroleukemia cell line that undergoes G1 phase arrest and subsequent apoptosis after p53 expression. Independently, PIDD was also described as a DD-containing protein with unknown function. The N-terminal region of PIDD contains seven leucine-rich repeats (LRRs), a protein interaction motif found in various proteins with diverse functions, followed by two ZU-5 domains and a C-terminal DD. PIDD forms a complex with caspase-2 and the adaptor protein RAIDD. Increased PIDD expression results in spontaneous activation of caspase-2 and sensitization to apoptosis by genotoxic stimuli, via interaction with caspase-2 and CRADD/RAIDD. PIDD also promotes apoptosis downstream of p53 as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis. PIDD has also been shown to interact with NEMO/IKBKG and RIP1 and enhance sumoylation and ubiquitination of NEMO/IKBKG, an important component for activation of the transcription factor NF-kappa-B. Function: Promotes apoptosis downstream of the tumor suppressor as component of the DNA damage/stress response pathway that connects p53/富含亮氨酸重复死亡结构域蛋白抗体TP53 to apoptosis. Associates with NEMO/IKBKG and RIP1 and enhances sumoylation and ubiquitination of NEMO/IKBKG which is important for activation of the transcription factor NF-kappa-B. Associates with CASP2/caspase-2 and CRADD/RAIDD, and induces activation of CASP2 which an important regulator in apoptotic pathways. Subunit: Interacts with FADD and MAP-kinase activating death domain/MADD. Forms a complex with IKBKG and with receptor-interacting serine-threonine kinase 1/RIP1. Forms also a complex named PIDDosome with 富含亮氨酸重复死亡结构域蛋白抗体CASP2 and CRADD. Subcellular Location: Cytoplasm. Nucleus. Tissue Specificity: Ubiquitous. Similarity: Contains 1 death domain. Contains 7 LRR (leucine-rich) repeats. Contains 1 peptidase S68 domain. Contains 2 ZU5 domains. Gene ID: 55367 Database links: Entrez Gene: 55367 Human Entrez Gene: 57913 Mouse Entrez Gene: 293625 Rat Omim: 605247 Human SwissProt: Q9HB75 Human SwissProt: Q9ERV7 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
富含亮氨酸重复死亡结构域蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 细胞凋亡
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid