富含脯氨酸/丝氨酸卷曲螺旋蛋白1抗体
规格：1mg/1ml
英文名： PSRC1
别名： DDA3; Differential display and activated by p53; FP3214; p53-regulated DDA3; Proline/serine-rich coiled-coil 1; proline/serine-rich coiled-coil protein 1; PSRC1_HUMAN.
分子量： 39kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PSRC1
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Rabbit,
细胞定位：细胞浆
富含脯氨酸/丝氨酸卷曲螺旋蛋白1抗体产品介绍：background: This gene encodes a proline rich protein. Studies of the related mouse gene suggest that this gene is regulated by p53 and may participate in p53 mediated growth suppression. Alternatively spliced transcript variants encoding different isoforms have been described. Function: Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation富含脯氨酸/丝氨酸卷曲螺旋蛋白1抗体 of normal tension across sister kinetochores. Recruits KIF2A to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression. Subunit: Interacts with APC2 (By similarity). Interacts with KIF2A. Subcellular Location: Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Detected at the mitotic spindle and spindle poles. Diffusely distributed throughout the cell during interphase. Tissue Specificity: Widely expressed in ***** and fetal tissues, with highest expression 富含脯氨酸/丝氨酸卷曲螺旋蛋白1抗体in the ***** brain and fetal thymus. Not detected in ***** skeletal muscle. Post-translational modifications: Phosphorylated during mitosis. Similarity: Belongs to the PSRC1 family. Database links: UniProtKB/Swiss-Prot: Q6PGN9.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
富含脯氨酸/丝氨酸卷曲螺旋蛋白1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 细胞凋亡 细胞周期蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid