丙型肝炎病毒非结构蛋白5A反式激活蛋白9抗体
规格：1mg/1ml
英文名： NS5ATP9
别名： L5 antibody PAF; HCV NS5A transactivated protein 9; Hepatitis C virus NS5A transactivated protein 9; NS5 ATP9; NS5ATP9; OEATC 1; Overexpressed in anaplastic thyroid carcinoma 1; p15(PAF); p15PAF; PCNA
分子量： 12kDa
产品介绍MSDS与**信息质检证书(COA)相关产品
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human NS5ATP9/
交叉反应：Human, Mouse, Rat, Pig, Cow, Sheep,
细胞定位：细胞核 细胞浆
丙型肝炎病毒非结构蛋白5A反式激活蛋白9抗体产品介绍：background: NS5ATP9/PAF/p15(PAF) is involved in protection of cells from UV-induced cell death and is also a Hepatitis C NS5A up-regulation gene which may play a role in the pathogenesis of HCV-associated hepatocellular carcinoma. Function: PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number. Subunit: Interacts (when monoubiquitinated at Lys-15 and Lys-24) with PCNA. Interacts with isoform 2/p33ING1b of ING1. Interacts with BRCA1. Subcellular Location: Nucleus. Cytoplasm, perinuclear region. Note=Following DNA damage, localizes to DNA damage sites. Colocalizes with centrosomes丙型肝炎病毒非结构蛋白5A反式激活蛋白9抗体 in perinuclear region. Tissue Specificity: Expressed predominantly in liver, pancreas and placenta. Not detected in heart or brain. Highly expressed in a number of tumors, especially esophageal tumors, in anaplastic thyroid carcinomas, adrenocortical carcinomas, and in non-small-cell lung cancer lines. Post-translational modifications: Monoubiquitinated at Lys-15 and Lys-24 during normal S phase, promoting its association with PCNA. Also diubiquitinated at these 2 sites. Following DNA damage, monoubiquitin chains at Lys-15 and Lys-24 are 丙型肝炎病毒非结构蛋白5A反式激活蛋白9抗体probably extended, leading to disrupt the interaction with PCNA. Polyubiquitinated by the APC/C complex at the mitotic exit, leading to its degradation by the proteasome. Database links: UniProtKB/Swiss-Prot: Q15004.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
丙型肝炎病毒非结构蛋白5A反式激活蛋白9抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 染色质和核信号 细胞凋亡 **及病毒
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid