α1,4-半乳糖基转移酶1

α1,4-半乳糖基转移酶1

规格：1mg/1ml

英文名： A4GALT

别名： 4 N acetylglucosaminyltransferase; 4-galactosyltransferase; 4-N-acetylglucosaminyltransferase; A14GALT; A4GALT; A4GALT1; A4GAT_HUMAN; Alpha 1 4 galactosyltransferase; Alpha 1 4 N acetylglucosaminyltra

分子量： 40kDa

储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆类型：Polyclonal

亚型：IgG

纯化方法：affinity purified by Protein A

**原：KLH conjugated synthetic peptide derived from human A4GALT/C

交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig,

细胞定位：细胞浆 细胞膜

α1,4-半乳糖基转移酶1产品介绍：background: Necessary for the biosynthesis of the Pk antigen of blood histogroup P. Catalyzes the transfer of galactose to lactosylceramide and galactosylceramide. Necessary for the synthesis of the receptor for bacterial verotoxins.Expression of CD77, also called Gb3, sensitizes a cell to verotoxins, causing cellular injury that can lead to disease. Therefore, the complex regulation of CD77 biosynthesis and the activity of the enzymes involved, such as CD77 synthase, can be studied by compared gene expression between toxin-sensitive and insensitive tissues and cell lines. The highest tissue expression of CD77 synthase occurs in the kidney, mesenteric lymph node, spleen, and brain. Burkitt leukemia cells express very high levels of CD77 as well as CD77 synthase, and are sensitive to verotoxin induced apoptosis. These megakaryoblasts then never mature, leading to the arrest of platelet generation in the bone marrow, which may cause thrombocytopenia, a symptom associated with various hemorrhagic conditions. Function: Necessary for the biosynthesis of the Pk antigen of blood histogroup P.α1,4-半乳糖基转移酶1 Catalyzes the transfer of galactose to lactosylceramide and galactosylceramide. Necessary for the synthesis of the receptor for bacterial verotoxins. Subcellular Location: Golgi apparatus membrane; Single-pass type II membrane protein (Probable). Tissue Specificity: Ubiquitous. Highly expressed in kidney, heart, spleen, liver, testis and placenta. Similarity: Belongs to the glycosyltransferase 32 family. Geneα1,4-半乳糖基转移酶1 ID: 53947 Database links: Entrez Gene: 53947 Human Entrez Gene: 239559 Mouse Entrez Gene: 63888 Rat Omim: 607922 Human SwissProt: Q9NPC4 Human SwissProt: Q67BJ4 Mouse SwissProt: Q9JI93 Rat Unigene: 105956 Human Unigene: 323805 Mouse Unigene: 48584 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

α1,4-半乳糖基转移酶1产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:20-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究领域：心血管  细胞生物  细胞表面分子  

储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

来源： Rabbit

外观： Lyophilized or Liquid

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