IKK激酶相互作用蛋白抗体
规格：1mg/1ml
英文名： IKIP
别名： I kappa B kinase interacting protein; IKIP1; IKIP2; IKIP3; IKK interacting protein; IKIP_HUMAN.
分子量： 39kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human IKIP (26
交叉反应：Human, Mouse, Rat, Cow, Horse, Sheep,
细胞定位：细胞浆 细胞膜
IKK激酶相互作用蛋白抗体产品介绍：background: IKIP (I kappa B kinase interacting protein)is located on chromosome 12 in close proximity to APAF1 (apoptotic protease-activating factor-1). IKIP was originally cloned from a yeast two hybrid screening as an IKK2 interacting protein. IKIP and APAF1 share a common 488 bp promoter from which the two genes are transcribed in opposite directions, presumably in a co-regulated manner. Three IKIP transcripts are generated by differential splicing and alternative exon usage and show no significant homology to other genes. IKIP is expressed predominantly in the lung, kidney, spleen, thymus and skeletal muscle. Like APAF1, expression of IKIP is enhanced by irradiation, in a p53-dependent manner. When transfected into endothelial cells IKIP promotes apoptosis suggesting that it plays a role in the cell death process as well as NF-kB regulation. Function: Target of p53/TP53 with pro-apoptotic function. Subcellular Location: IKK激酶相互作用蛋白抗体Endoplasmic reticulum membrane; Single-pass membrane protein. Note=Isoform 4 deletion of the hydrophobic, or transmembrane region between AA 45-63 results in uniform distribution throughout the cell, suggesting that this region is responsible for endoplasmic reticulum localization. Tissue Specificity: Expressed in vein endothelial cells. Isoform 4 is expressed in lung, kidney, spleen, thymus and skeletal muscle. IKK激酶相互作用蛋白抗体Post-translational modifications: Isoform 4 may be phosphorylated at Thr-362 by similarity with mouse isoform 1. N-glycosylated. Isoform 4 is glycosylated at Asn-154. Database links: UniProtKB/Swiss-Prot: Q70UQ0.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
IKK激酶相互作用蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 细胞凋亡 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid