血小板源性生长因子AB+BB抗体
规格：1mg/1ml
英文名： PDGF AB+BB
别名： PDGF AB + BB; PDGF 1; PDGF 2; PDGF A; PDGF A chain; PDGF B chain; PDGF subunit A; PDGF subunit B; PDGF1; PDGF2; PDGFA; PDGFB; PDGFR1; Platelet derived growth factor 2; Platelet derived growth factor a
分子量： 14kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：Purified human PDGF-AB
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse,
细胞定位：
血小板源性生长因子AB+BB抗体产品介绍：background: Platelet-Derived Growth Factor (PDGF) is the major serum mitogen for cells of mesenchymal origin in humans. The biologically active protein is a dimer composed of two related polypeptides designated A and B. The PDGF protein has been implicated both directly as well as indirectly in several pathological states including neoplasia, arthritis, arteriosclerosis and bone marrow sclerosis. Function: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is 血小板源性生长因子AB+BB抗体modulated by the formation of heterodimers with PDGFB (By similarity). Subunit: Homodimer; antiparallel disulfide-linked dimer. Heterodimer with PDGFB; antiparallel disulfide-linked dimer. The PDGFA homodimer interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB. The heterodimer composed of PDGFA and PDGFB interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB. Interacts with CSPG4. Subcellular Location: Secreted. Note=Released by platelets upon wounding. Similarity: Belongs to 血小板源性生长因子AB+BB抗体the PDGF/VEGF growth factor family. Gene ID: 5154; 5155 Database links: Entrez Gene: 5154 Human Entrez Gene: 5155 Human Entrez Gene: 18590 Mouse Entrez Gene: 18591 Mouse Entrez Gene: 24628 Rat Entrez Gene: 25266 Rat Omim: 173430 Human Omim: 190040 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
血小板源性生长因子AB+BB抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 心血管 细胞生物 **学 发育生物学 神经生物学 信号转导 生长因子和** 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid