肿瘤坏死因子α诱导蛋白3相互作用蛋白2抗体
规格：1mg/1ml
英文名： TNIP2
别名： A20 binding inhibitor of NF kappaB activation 2; ABIN 2; FLIP1; KLIP; LKB1 interacting protein; TNFAIP3 interacting protein 2; TNIP2_MOUSE.
分子量： 49kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TNIP2/AB
交叉反应：Human, Mouse, Rat, Dog, Horse,
细胞定位：
肿瘤坏死因子α诱导蛋白3相互作用蛋白2抗体产品介绍：background: The human TNIP2 (also known as ABIN-2), which is related to proteins ABIN-1 and ABIN-3, was originally identified as an A20-associating cytosolic protein that block nuclear factor kappaB (NF-kB) activation. NF-kB plays a central role in the regulation of genes implicated in immune responses, inflammatory processes, and apoptotic cell death and the zinc finger protein A20 is a potent inhibitor of NF-kB activity with a key role in limiting the extent and duration of inflammatory activation. It was also reported that ABIN-2 has the potential to enter the nucleus and plays a role in mediating transcriptional activation in both yeast and mammalian cells. Function: Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional肿瘤坏死因子α诱导蛋白3相互作用蛋白2抗体 coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes. Subunit: nteracts with STK11/LKB1, TNFAIP3, IKBKG, NFKB1, MAP3K8, TEK, RIPK1, CHUK, IKBKB and SMARCD1. Interacts with polyubiquitin Tissue Specificity: Ubiquitously expressed in all tissues examined. Post-translational modifications: In vitro phosphorylated by CHUK (By similarity). Ubiquitinated; undergoes 'Lys-48'-linked polyubiquitination probably leading to constitutive proteasoma肿瘤坏死因子α诱导蛋白3相互作用蛋白2抗体l degradation which can be impaired by IKK-A/CHUK or IKBKB probbaly involving deubiquitination (By similarity). Gene ID: v Database links: Entrez Gene: 79155 Human Entrez Gene: 231130 Mouse Omim: 610669 Human SwissProt: Q8NFZ5 Human SwissProt: Q99JG7 Mouse Unigene: 726088 Human Unigene: 28615 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
肿瘤坏死因子α诱导蛋白3相互作用蛋白2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 信号转导 转录调节因子 内皮细胞 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid