B细胞粘附分子CD239抗体
规格：1mg/1ml
英文名： CD239
别名： Antigen identified by monoclonal antibody F8; AU antibody Auberger B antigen; B CAM cell surface glycoprotein; B cell adhesion molecule; B-CAM cell surface glycoprotein; Basal cell adhesion molecule;
分子量： 64kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CD239
交叉反应：Human, Mouse, Rat, Dog, Cow,
细胞定位：细胞膜
B细胞粘附分子CD239抗体产品介绍：background: This gene encodes Lutheran blood group glycoprotein, a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five extracellular immunoglobulin domains, a single transmembrane domain, and a short C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Polymorphisms in this gene define some of the antigens in the Lutheran system and also the Auberger system. Inactivating variants of this gene result in the recessive Lutheran null phenotype, Lu(a-b-), of the Lutheran blood group. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]. Function: Laminin alpha-5 receptor. May mediate intracellular signaling. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Wide tissue distributionB细胞粘附分子CD239抗体 (highest in the pancreas and very low in brain). Closely associated with the basal layer of cells in epithelia and the endothelium of blood vessel walls. Post-translational modifications: Epinephrine-stimulated phosphorylation of Ser-621 by PKA enhances adhesion to laminin. Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains. Contains 2 Ig-like V-type (immunoglobulin-like) domains. Gene ID: B细胞粘附分子CD239抗体4059 Database links: Entrez Gene: 4059 Human Entrez Gene: 57278 Mouse Entrez Gene: 78958 Rat Omim: 612773 Human SwissProt: P50895 Human SwissProt: Q9R069 Mouse SwissProt: Q9ESS6 Rat Unigene: 625725 Human Unigene: 29236 Mouse Unigene: 7003 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
B细胞粘附分子CD239抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 细胞生物 信号转导 细胞膜受体 细胞粘附分子 细胞表面分子 血管内皮细胞
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid