肿瘤坏死因子α诱导相互作用蛋白3抗体
规格：1mg/1ml
英文名： TNFAIP3 interacting protein 3
别名： Listeria induced; A20-binding inhibitor of NF-kappa-B activation 3; ABIN-3; ABIN-3 beta; FLJ21162; LIND; Listeria induced gene protein; TNFAIP3 interacting protein 3; TNFAIP3-interacting protein 3 bet
分子量： 39kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TNFAIP3
交叉反应：Human, Mouse, Rat, Cow, Sheep,
细胞定位：
肿瘤坏死因子α诱导相互作用蛋白3抗体产品介绍：background: ABIN-3 is a member of the A20-binding inhibitor of NF-kappaB activation (ABIN) protein family. Similar to the previously characterized human ABINs (ABIN-1 and ABIN-2), ABIN-3 can bind to A20 and inhibit NF-kappaB activation. In contrast, mouse ABIN-3 is incapable of inhibiting NF-kappaB activation by proinflammatory stimuli because the protein lacks a complete ABIN homology domain, which is required for the funcitonal activity of human ABIN-3. Function: Binds to zinc finger protein TNFAIP3 and inhibits NF-kappa-B activation induced by tumor necrosis factor, Toll-like receptor 4 (TLR4), interleukin-1 and 12-O-tetradecanoylphorbol-13-acetate. Overexpression inhibits NF-kappa-B-dependent gene expression in response to lipopolysaccharide at a level downstream of TRAF6 and upstream of IKBKB. NF-kappa-B inhibition is independent of TNFAIP3 binding. Subunit: Interacts with TNFAIP3. Interacts with polyubiquitin.肿瘤坏死因子α诱导相互作用蛋白3抗体 Tissue Specificity: Highly expressed in lung, lymph node, thymus and fetal liver. Expressed at lower levels in bone marrow, brain, kidney, spleen, leukocytes and tonsils. Could be detected in heart, salivary gland, adrenal gland, pancreas, ovary and fetal brain. High levels detected in liver, colon, small intestine, muscle, stomach, testis, placenta, thyroid, uterus, prostate, skin and PBL. Gene ID: 肿瘤坏死因子α诱导相互作用蛋白3抗体79931 Database links: Entrez Gene: 79931 Human Entrez Gene: 414084 Mouse Omim: 608019 Human SwissProt: Q96KP6 Human Unigene: 208206 Human Unigene: 117558 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
肿瘤坏死因子α诱导相互作用蛋白3抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 染色质和核信号 信号转导 转录调节因子 内皮细胞
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid
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