5脂氧合酶激活蛋白抗体
规格：1mg/1ml
英文名： FLAP
别名： 5-lipoxygenase activating protein; Arachidonate 5 lipoxygenase activating protein; 5-lipoxygenase activating protein; AL5AP_HUMAN; ALOX 5AP; ALOX5 AP; ALOX5AP; Arachidonate 5-lipoxygenase-activating p
分子量： 18kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human FLAP/5-l
交叉反应：Human, Mouse, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞核 细胞浆 细胞膜
5脂氧合酶激活蛋白抗体产品介绍：background: Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes. Involvement in disease: Genetic variations in ALOX5AP may be a cause of susceptibility to ischemic stroke (ISCHSTR) ; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Function: Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes. Subunit: Homotrimer. Interacts with LTC4S and ALOX5. Subcellular Location: Nucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. DISEASE: Genetic variations in ALOX5AP may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:601367];5脂氧合酶激活蛋白抗体 also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Note=Genetic variations in ALOX5AP may be associated with susceptibility to myocardial infarction. Involvement in myocardial infarction is however unclear: according to some authors (PubMed:14770184), a 4-SNP haplotype in ALOX5AP confers risk of myocardial infarction, while according to other (PubMed:17304054) ALOX5AP is not implicated in this condition. Similarity: Belongs to the MAPEG family. Gene ID: 241 Database links: Entrez Gene: 477323 Dog Entrez Gene:5脂氧合酶激活蛋白抗体 241 Human Omim: 603700 Human SwissProt: Q2PG08 Cynomolgus Monkey SwissProt: P30353 Horse SwissProt: P20292 Human SwissProt: P30354 Macaque Monkey SwissProt: P30357 Rabbit Unigene: 507658 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
5脂氧合酶激活蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 细胞生物 **学 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid