磷酸化细胞质膜微囊蛋白-2抗体
规格：1mg/1ml
英文名： phospho-Caveolin-2(Tyr19)
别名： Caveolin 2 (phospho Y19); p-Caveolin 2(phospho Y19); CAV; CAV2; CAV2_HUMAN; Caveolae protein 20 kD; Caveolin 2; Caveolin 2 isoform a and b; Caveolin 2 isoform c; Caveolin-2; MGC12294; CAV2_HUMAN.
分子量： 18kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated Synthesised phosphopeptide derived from mouse
交叉反应：Mouse, Rat,
细胞定位：
磷酸化细胞质膜微囊蛋白-2抗体产品介绍：background: Cellular localization: Nucleus. Cytoplasm. Golgi apparatus membrane. Cell membrane. Membrane > caveola. Potential hairpin-like structure in the membrane. Membrane protein of caveolae. Tyr-19-phosphorylated form is enriched at sites of cell-cell contact and is translocated to the nucleus in complex with MAPK1 in response to insulin (By similarity). Tyr-27-phosphorylated form is located both in the cytoplasm and plasma membrane. CAV1-mediated Ser-23-phosphorylated form locates to the plasma membrane. Ser-36-phosphorylated form resides in intracellular compartments. Function: May act as a scaffolding protein within caveolarmembranes. Interacts directly with G-protein alpha subunits and canfunctionally regulate their activity. Acts as an accessory proteinin conjunction with CAV1 in targeting to lipid rafts and drivingcaveolae formation. The Ser-36 phosphorylated form has a role inmodulating mitosis in endothelial cells. Positive regulator ofcellular mitogenesis of the MAPK signaling pathway. Required forthe insulin-stimulated nuclear translocation and activation ofMAPK1 and STAT3, and the subsequent regulation of cell cycleprogression (By similarity). Subunit: Monomer or homodimer. Interacts with CAV1; theinteraction forms a stable heterooligomeric complex that isrequired for targeting to lipid rafts and for caveolae formation.Tyrosine phosphorylated forms do not form heterooligomers with theTyr-19-phosphorylated form existing as a monomer or dimer, and theTyr-27-form as a monomer only. Interacts (tyrosine phosphorylatedform) with the SH2 domain-containing proteins, RASA1, NCK1 and SRC.Interacts (tyrosine phosphorylated form) with INSR, the interaction磷酸化细胞质膜微囊蛋白-2抗体(Tyr-27-phosphorylated form) is increased on insulin stimulation.Interacts (Tyr-19 phosphorylated form) with MAPK1 (phosphorylatedform); the interaction, promoted by insulin, leads to nuclearlocation and MAPK1 activation. Interacts with STAT3; theinteraction is increased on insulin-induced tyrosinephosphorylation leading to STAT activation (By similarity). Subcellular Location: Nucleus. Cytoplasm. Golgi apparatusmembrane; Peripheral membrane protein. Cell membrane; Peripheralmembrane protein. Membrane, caveola; Peripheral membrane protein.Note=Potential hairpin-like structure in the membrane. Membraneprotein of caveolae. Tyr-19-phosphorylated form is enriched atsites of cell-cell contact and is translocated to the nucleus incomplex with MAPK1 in response to insulin (By similarity).Tyr-27-phosphorylated form is located both in the cytoplasm andplasma membrane. CAV1-mediated Ser-23-phosphorylated form locatesto the plasma membrane. Ser-36-phosphorylated form resides inintracellular compartments. Tissue Specificity: Expressed in endothelial cells, smooth musclecells, skeletal myoblasts and fibroblasts. Post-translational modifications: Phosphorylated on serine and tyrosine residues. CAV1 promotesphosphorylation on Ser-23 which then targets the complex to theplasma membrane, lipid rafts and caveolae. Phosphorylation onSer-36 appears to modulate mitosis in endothelial cells (Bysimilarity). Phosphorylation on both Tyr-19 and Tyr-27 is requiredfor insulin-induced 'Ser-727' phosphorylation of STAT3 and itsactivation. Phosphorylation on Tyr-19 is required forinsulin-induced phosphorylation of MAPK1 and DNA binding of STAT3.Tyrosine phosphorylation is induced by both EGF and insulin (Bysimilarity). Similarity: Belongs to the caveolin family. Database links: UniProtKB/Swiss-Prot: P51636.2 Entrez Gene: 858 Human Entrez Gene: 12390 Mouse Entrez Gene: 1磷酸化细胞质膜微囊蛋白-2抗体00362824 Rat Entrez Gene: 363425 Rat Omim: 601048 Human SwissProt: P51636 Human SwissProt: Q9WVC3 Mouse SwissProt: Q2IBC5 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Caveolin是细胞生长相关信号途径及肿瘤发**展过程中重要磷酸化细胞质膜微囊蛋白-2抗体的抑制因子，Caveolae是细胞膜内的特殊膜结构，参与包括细胞的分子运输、细胞粘附和信号转导在内的多种细胞活动。Caveolin-1是Caveolae中重要的结构蛋白，抑制细胞生长，与多种人类肿瘤发**展相关的信号分子相互作用。Caveolin在信号转导的整合中起支架蛋白的作用。Caveolin构成了一个蛋白家族，他们是细胞质膜中发夹样结构域的主要结构成分。Caveolin在信号转导的整合中起支架蛋白的作用。至今已经鉴定了3种Caveolin （Caveolin-1、2 和3），它们具有不同的组织分布。
产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 细胞生物 信号转导 细胞凋亡
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid