WDR35蛋白抗体

WDR35蛋白抗体

规格：1mg/1ml

英文名： WDR35

别名： Intraflagellar transport protein 121 homolog; KIAA1336; MGC33196; Naofen; WD repeat domain 35; WD repeat-containing protein 35; WDR35; WDR35_HUMAN.

分子量： 133kDa

储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆类型：Polyclonal

亚型：IgG

纯化方法：affinity purified by Protein A

**原：KLH conjugated synthetic peptide derived from human WDR35

交叉反应：Human, Mouse, Rat, Dog, Cow, Rabbit, Sheep,

细胞定位：细胞浆

WDR35蛋白抗体产品介绍：background: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Two patients with Sensenbrenner syndrome / cranioectodermal dysplasia (CED) were identified with mutations in this gene, consistent with a possible ciliary function.[provided by RefSeq, Sep 2010] Function: May promote CASP3 activation and TNF-stimulated apoptosis. DISEASE: Defects in WDR35 are the cause of cranioectodermal dysplasia type 2 (CED2) [MIM:613610]. A disorder characterized by craniofacial, skeletal and WDR35蛋白抗体ectodermal abnormalities. Clinical features include short stature, dolichocephaly, craniosynostosis, narrow thorax with pectus excavatum, short limbs, brachydactyly, joint laxity, narrow palpebral fissures, telecanthus with hypertelorism, low-set simple ears, everted lower lip, and short neck. Teeth abnormalities included widely spaced, hypoplastic and fused teeth. Similarity: Contains 5 WD repeats. Gene ID: 57539 Database links: Entrez Gene: 57539 Human Entrez Gene: 74682 Mouse Entrez Gene: 298876 Rat Entrez Gene: 503018 Rat Omim: 613602 Human SwissProt:WDR35蛋白抗体 Q9P2L0 Human SwissProt: Q8BND3 Mouse SwissProt: A6N6J5 Rat Unigene: 205427 Human Unigene: 87389 Mouse Unigene: 104271 Rat Unigene: 14574 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

WDR35蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究领域：细胞生物  **学  信号转导  细胞凋亡  细胞周期蛋白  

储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

来源： Rabbit

外观： Lyophilized or Liquid

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