Kelch样蛋白20抗体
规格：1mg/1ml
英文名： KLHL20
别名： Kelch like ECT2 interacting protein; Kelch like protein 20; Kelch like protein X; Kelch motif containing protein; Kelch-like ECT2-interacting protein; Kelch-like protein 20; Kelch-like protein X; KHLH
分子量： 68kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human KLHL20
交叉反应：Human, Mouse, Rat, Chicken, Cow, Rabbit, Sheep,
细胞定位：细胞核 细胞浆
Kelch样蛋白20抗体产品介绍：background: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of DAPK1, leading to its degradation by the proteasome, thereby acting as a negative regulator of apoptosis. Also acts as a regulator of endothelial migration during angiogenesis by controlling the activation of Rho GTPases. Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of DAPK1, leading to its degradation by the proteasome, thereby acting as a negative regulator of apoptosis. Also acts as a regulator of endothelial migration during angiogenesis by controlling the activation of Rho GTPases. Subunit: Component of the BCR(KLHL20) E3 ubiquitin ligase complex, at least composed of CUL3,Kelch样蛋白20抗体 KLHL20 and RBX1. Interacts with DAPK1. Interacts with F-actin. Interacts with IFN-gamma (IFNG). Subcellular Location: Cytoplasm, perinuclear region. Nucleus. Note=Localizes in the perinuclear region in normal conditions. Following IFN-alpha or IFN-gamma treatment, it is relocalized and sequestrated to the PML nuclear bodies, preventing DAPK1 ubiquitination. Similarity: Contains 1 BACK (BTB/Kelch associated) domain. Kelch样蛋白20抗体Contains 1 BTB (POZ) domain. Contains 6 Kelch repeats. Database links: UniProtKB/Swiss-Prot: Q9Y2M5.4 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Kelch样蛋白20抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 细胞生物 信号转导 血管内皮细胞 细胞外基质
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid