白细胞衍生化学吸引素抗体
规格：1mg/1ml
英文名： LECT1
别名： Chondromodulin I; BRICD3; BRICHOS domain containing 3; CHM I; CHM1; chondromodulin; Chondrosurfactant protein; LECT 1; Leukocyte cell derived chemotaxin 1; LECT1_HUMAN.
分子量： 14kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human LECT1
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Guinea Pig,
细胞定位：细胞膜 分泌型蛋白
产品介绍：background: The LECT1 gene encodes a glycosylated transmembrane protein which is cleaved to form a mature, secreted protein. The N 白细胞衍生化学吸引素抗体terminus of the precursor protein shares characteristics with other surfactant proteins and is sometimes called chondrosurfactant protein, although no biological activity has yet been defined for it. The C terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell derived chondromodulin 1 or chemotaxin 1. The mature protein inhibits angiogenesis and promotes chondrocyte growth. This gene is expressed in the avascular zone of prehypertrophic cartilage and its expression decreases during chondrocyte hypertrophy and vascular invasion. The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone. It may be involved also in the broad control of tissue vascularization during development. Alternative splicing results in multiple transcript variants encoding different isoforms. Function: Bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the growth of cultured vascular endothelial cells. May contribute to the白细胞衍生化学吸引素抗体 rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development. Subcellular Location: Chondromodulin-1: Secreted. Note=Accumulated in the inter-territorial matrix of cartilage. Chondrosurfactant protein: Endomembrane system; Single-pass membrane protein (Potential). Tissue Specificity: Cartilage specific. Weakly expressed in 白细胞衍生化学吸引素抗体chondrosarcoma. Similarity: Belongs to the chondromodulin-1 family. Contains 1 BRICHOS domain. Database links: UniProtKB/Swiss-Prot: O75829.1 Entrez Gene: 11061 Human Entrez Gene: 16840 Mouse Omim: 605147 Human SwissProt: O75829 Human SwissProt: Q9Z1F6 Mouse Unigene: 421391 Human Unigene: 46561 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
白细胞衍生化学吸引素抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 心血管 细胞生物 **学 细胞周期蛋白 细胞骨架 细胞外基质
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid