微管相关蛋白2a + 2b + 2c抗体
规格：1mg/1ml
英文名： MAP 2a + 2b + 2c
别名： MAP 2; MAP-2; MAP2; MAP2_HUMAN; MAP2A; MAP2B; MAP2C; MAP2R; Microtubule associated protein 2; Microtubule-associated protein 2; MAP2a + MAP2b + MAP2c; Mtap2.
分子量： 53kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MAP 2a +
交叉反应：Human,
细胞定位：细胞浆
微管相关蛋白2a + 2b + 2c抗体产品介绍：background: This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2010] Function: The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. Subcellular Location: Cytoplasm; cytoskeleton. Post-translational modifications:微管相关蛋白2a + 2b + 2c抗体 Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly (By similarity). MAP2A/c is phosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR. Isoform MAP2c is phosphorylated by FYN at Tyr-67. Similarity: Contains 3 Tau/MAP repeats. Gene ID: 4133 Database links: Entrez Gene: 4133 Human Entrez Gene: 281294 Cow Entrez Gene: 25595 Rat Omim: 157130 Human SwissProt: P11137 Human SwissProt: 微管相关蛋白2a + 2b + 2c抗体P15146 Rat Unigene: 368281 Human Unigene: 10484 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
微管相关蛋白2a + 2b + 2c抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 神经生物学 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid