疣状表皮发育**蛋白1抗体
规格：1mg/1ml
英文名： TMC6
别名： Epidermodysplasia verruciformis protein 1; EV1; EVER1; EVIN1; TMC6_HUMAN; LAK 4P; LAK4P; Protein LAK 4; Protein LAK4; Transmembrane channel like protein 6.
分子量： 90kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TMC6
交叉反应：Human, Mouse, Rat,
细胞定位：细胞膜
疣状表皮发育**蛋白1抗体产品介绍：background: Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 10 transmembrane domains and 2 leucine zipper motifs. [provided by RefSeq, Jul 2008] Function: Defects in TMC6 are a cause of epidermodysplasia verruciformis, a rare autosomal recessive genodermatosis associated with a high risk of skin carcinoma that results from an abnormal susceptibility to infection by specific human papillomaviruses. Infection leads to persistent wart-like or macular lesions. TMC6 is expressed in placenta, prostate, testis, activated T-lymphocytes and lymphokine-activated killer (LAK) lymphocytes. There are four named isoforms. Subcellular Location: Endoplasmic reticulum membrane; Multi-pass membrane protein Tissue Specificity: Expressed in placenta, prostate, testis, 疣状表皮发育**蛋白1抗体activated T-lymphocytes and lymphokine-activated killer (LAK) lymphocytes. DISEASE: Epidermodysplasia verruciformis (EV) [MIM:226400]: Rare autosomal recessive genodermatosis associated with a high risk of skin carcinoma that results from an abnormal susceptibility to infection by specific human papillomaviruses. Infection leads to persistent wart-like or macular lesions. Note=The disease is caused 疣状表皮发育**蛋白1抗体by mutations affecting the gene represented in this entry. Similarity: Belongs to the TMC family. Gene ID: 11322 Database links: Entrez Gene: 11322 Human Entrez Gene: 217353 Mouse Omim: 605828 Human SwissProt: Q7Z403 Human SwissProt: Q7TN60 Mouse Unigene: 632227 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
疣状表皮发育**蛋白1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 跨膜蛋白 细胞膜蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid