谷氨酸受体2+谷氨酸受体3抗体
规格：1mg/1ml
英文名： GLUR2 + GLUR3
别名： AMPA selective glutamate receptor 2; GRIA2_HUMAN; GRIA2_HUMAN; AMPA selective glutamate receptor 3; Ionotropic glutamate receptor 2 + 3; G protein coupled receptor family C group 1 member B; G protein
分子量： 96/98kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human GLUR2 +
交叉反应：Human, Mouse, Rat, Dog,
细胞定位：细胞膜
谷氨酸受体2+谷氨酸受体3抗体产品介绍：background: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008] Function: Ion channels activated by谷氨酸受体2+谷氨酸受体3抗体 glutamate are typically divided into two classes. Those sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by a-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR). AMPAR are comprised of four distinct Glutamate Receptor Subunits (GluR1-4) and they play key roles in almost all excitatory neurotransmission in the brain. The GluR2 subunit is widely expressed throughout the nervous system where it is thought to play key roles in synaptic plasticity and learning 谷氨酸受体2+谷氨酸受体3抗体and memory. Subcellular Location: Cell Membrane; multi-pass membrane protein. Gene ID: 2891/2892 Database links: Entrez Gene: 2891 Human Entrez Gene: 2892 Human Entrez Gene: 14800 Mouse Entrez Gene: 29627 Rat Omim: 138247 Human Omim: 305915 Human SwissProt: P42262 Human SwissProt: P42263 Human SwissProt: P23819 Mouse SwissProt: Q4LG64 Mouse SwissProt: Q80VM6 Mouse SwissProt: P19491 Rat Unigene: 32763 Human Unigene: 377070 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产谷氨酸受体2+谷氨酸受体3抗体品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 细胞膜受体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid