硫酯酶超家族成员4抗体
规格：1mg/1ml
英文名： THEM4
别名： Acyl CoA thioesterase THEM4; Acyl coenzyme A thioesterase THEM4; C terminal modulator protein; Carboxyl-terminal modulator protein; CTMP; FLJ27206; MGC29636; OTTHUMP; Them4; THEM4_HUMAN; Th
分子量： 27kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human THEM4
交叉反应：Human, Mouse, Rat,
细胞定位：细胞膜
硫酯酶超家族成员4抗体产品介绍：background: Protein kinase B (PKB) is a major downstream target of receptor tyrosine kinases that signal via phosphatidylinositol 3-kinase. Upon cell stimulation, PKB is translocated to the plasma membrane, where it is phosphorylated in the C-terminal regulatory domain. The protein encoded by this gene negatively regulates PKB activity by inhibiting phosphorylation. Transcription of this gene is commonly downregulated in glioblastomas. [provided by RefSeq, Jul 2008] Function: According to PubMed:11598301, inhibits AKT1 phosphorylation and activity. According to PubMed:17615157, enhances AKT1 activity by favoring its phosphorylation and硫酯酶超家族成员4抗体 translocation to plasma membrane. Subcellular Location: Cell membrane. Cell projection > ruffle membrane. Cytoplasm. Tissue Specificity: Expressed predominantly in skeletal muscle, testis, uterus, brain and kidney. Down-regulated in glioblastoma or glioma compared to non-neoplastic brain due to promoter hypermethylation. Post-translational modifications: Phosphorylated. Database links: Entrez Gene: 117145 Human Entrez Gene: 75778 Mouse Entrez Gene: 361992 Rat Omim: 606388 Human SwissProt: Q5T1C6 Human SwissProt: Q3UUI3 Mouse SwissProt: Q566R0 Rat Unigene:硫酯酶超家族成员4抗体 164070 Human Unigene: 45092 Mouse Unigene: 12625 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
硫酯酶超家族成员4抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 激酶和磷酸酶 结合蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid