自噬相关蛋白14抗体
规格：1mg/1ml
英文名： ATG14
别名： 4832427M01; ATG14; Atg14L; Autophagy-related protein 14-like protein; BAKOR_HUMAN; Barkor; Beclin 1-associated autophagy-related key regulator; D14Ertd114e; D14Ertd436e; KIAA0831; mCG_6911.
分子量： 55kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ATG14
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow,
细胞定位：细胞浆
自噬相关蛋白14抗体产品介绍：background: Required for both basal and inducible autophagy. Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine. Promotes BECN1 translocation from the trans-Golgi network to autophagosomes. Enhances PIK3C3 activity in a BECN1-dependent manner. Function: Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex. Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine. Promotes BECN1 translocation from the trans-Golgi network to autophagosomes. Enhances PIK3C3 activity in a BECN1-dependent manner. Subunit: Component of the autophagy-specific PI3-kinase complex I composed of ATG14, BECN1, PIK3C3 and PIK3R4, but not UVRAG, nor KIAA0226/Rubicon. UVRAG and ATG14/Barkor form mutually exclusive complexes with BECN1 through direct competition. The complex containing ATG14 up-regulates autophagy, while the one containing Rubicon down-regulates autophagy (By similarity). Interacts with PIK3CB (By similarity). Interacts with BECN1P1/BECN2. Subcellular Location: Cytoplasm. Endoplasmic reticulum. Cytosolic under nutrient-rich conditions.自噬相关蛋白14抗体 Following autophagy stimuli, such as starvation or rapamycin induction, predominantly detected in cytoplasmic foci, identified as isolation membranes and autophagosomes. Similarity: Belongs to the Barkor family. Gene ID: 22863 Database links: Entrez Gene: 22863 Human Entrez Gene: 100504663 Mouse Entrez Gene: 305831 Rat Omim: 613515 Human SwissProt: Q6ZNE5 Human SwissProt: Q8CDJ3 Mouse SwissProt: D4A4K3 Rat Unigene: 414809 Human Entrez Gene: 22863 Human Entrez Gene: 100504663 Mouse Entrez Gene: 305831 Rat Omim: 613515 Human SwissProt: 自噬相关蛋白14抗体Q6ZNE5 Hun SwissProt: Q8CDJ3 MouseSwissProt: D4A4K3 Rat Unigene: 414809 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
自噬相关蛋白14抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 细胞凋亡 转运蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid