转录因子THOC5抗体
规格：1mg/1ml
英文名： THOC5
别名： C22orf19; Chromosome 22 open reading frame 19; Fmip; Fms interacting protein; fSAP79; Functional spliceosome-associated protein 79; hTREX90; KIAA0983; LOC400922; NF2/meningioma region protein pK1.3; P
分子量： 79kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human THOC5
交叉反应：Human, Mouse, Rat, Chicken, Dog, Cow, Rabbit, Guinea Pig,
细胞定位：细胞核 细胞浆
转录因子THOC5抗体产品介绍：Function: Component the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via an interaction beteen KSHV ORF57 protein and ALYREF/THOC4. DDX39B functions as a bridge between ALYREF/THOC4 and the THO complex. THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA. Regulates the expression of myeloid transcription factors CEBPA, CEBPB and GAB2 by enhancing the levels of phosphatidylinositol 3,4,5-trisphosphate. May be involved in the differentiation of granulocytes and adipocytes. Essential for hematopoieti转录因子THOC5抗体c primitive cell survival and plays an integral role in monocytic development. Subcellular Location: Nucleus. Cytoplasm. Shuttles between nucleus and cytoplasm. Tissue Specificity: Ubiquitously expressed. Post-translational modifications: Phosphorylated on tyrosine upon binding to activated CSF1R; which causes a dissociation of the two proteins. Phosphorylation on Ser-5 and/or Ser-6 is required for nuclear export. Phosphorylated on Thr-328 in insulin-stimulated adipocytes (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Belongs转录因子THOC5抗体 to the THOC5 family. Database links: Entrez Gene: 8563 Human Entrez Gene: 107829 Mouse Entrez Gene: 360972 Rat Omim: 612733 Human SwissProt: Q13769 Human SwissProt: Q8BKT7 Mouse SwissProt: Q68FX7 Rat Unigene: 75361 Human Unigene: 28969 Mouse Unigene: 446885 Mouse Unigene: 14671 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
转录因子THOC5抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid