TAR结合蛋白1抗体
规格：1mg/1ml
英文名： TARBP1
别名： FLJ30482; Probable methyltransferase TARBP1; TAR (HIV) RNA binding protein 1; TAR; TAR RNA loop binding protein; TAR RNA-binding protein 1; TAR RNA-binding protein of 185 kDa; TARB1_HUMAN; TARBP1; TRM
分子量： 182kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TARBP1
交叉反应：Human,
细胞定位：细胞核
TAR结合蛋白1抗体产品介绍：background: HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. This element forms a stable stem-loop structure and can be bound by either the protein encoded by this gene or by RNA polymerase II. This protein may act to disengage RNA polymerase II from TAR during transcriptional elongation. Alternatively spliced transcripts of this gene may exist, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008] Function: Probable S-adenosyl-L-methionine-dependent methyltransferase TAR结合蛋白1抗体which methylates RNA molecules such as tRNAs. In case of infection by HIV-1, it binds to the loop region of TAR RNA, a region also bound by RNA polymerase II. Binding of TARBP1 and RNA polymerase II to HIV-1 TAR RNA is mutually exclusive, suggesting that TARBP1 may function alone or in conjunction with HIV-1 Tat to disengage RNA polymerase II from HIV-1 TAR RNA. May act by methylating HIV-1 TAR RNA. Subunit: Monomer and homodimer. Subcellular Location: nucleus. Similarity: Belongs to the RNA methyltransferase TrmH family. Database links: TAR结合蛋白1抗体Entrez Gene: 6894 Human Omim: 605052 Human SwissProt: Q13395 Human Unigene: 498115 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
TAR结合蛋白1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 转录调节因子 结合蛋白 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid