叶酸受体α/α-FR 抗体
规格：1mg/1ml
英文名： Folate Receptor alpha
别名： *****; Adult folate binding protein; Adult folate-binding protein; FBP; Folate Receptor 1 Adult; Folate receptor 1; Folate Receptor 1 Precursor; Folate receptor *****; Folate receptor alpha; Folate re
分子量： 27kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Folate R
交叉反应：Human, Rat, Cow, Rabbit, Sheep,
细胞定位：细胞浆 细胞膜
叶酸受体α/α-FR 抗体产品介绍：background: The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2009] Function: Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. Subcellular Location: Cell membrane. Secreted. Tissue Specificity: Exclusively expressed in tissues of epithelial origin. Expression is increased in malignant tissues.叶酸受体α/α-FR 抗体 Expressed in kidney, lung and cerebellum. Post-translational modifications: Eight disulfide bonds are present. The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease. DISEASE: Defects in FOLR1 are the cause of neurodegeneration due to cerebral folate transport deficiency (NCFTD) [MIM:613068]. NCFTD is an autosomal recessive disorder resulting from brain-specific folate deficiency early in life. Onset is apparent in late infancy with severe developmental regression, movement disturbances, epilepsy, and leukodystrophy. Note=Recognition and diagnosis of this disorder is critical because folinic acid therapy 叶酸受体α/α-FR 抗体can reverse the clinical symptoms and improve brain abnormalities and function. Similarity: Belongs to the folate receptor family. Gene ID: 2348 Database links: Entrez Gene: 2348 Human Omim: 136430 Human SwissProt: P15328 Human Unigene: 73769 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
叶酸受体α/α-FR 抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 信号转导 细胞膜受体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid