嗜酸性粒细胞颗粒关键碱性蛋白抗体
规格：1mg/1ml
英文名： PRG2
别名： BMPG; EMBP; Eosinophil granule major basic protein; Major Basic Protein; Eosinophil major basic protein; MBP; MBP1; Natural killer cell activator; Pregnancy-associated major basic protein; PRG 2; PRG2
分子量： 25kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PRG2
交叉反应：Human,
细胞定位：细胞浆
嗜酸性粒细胞颗粒关键碱性蛋白抗体产品介绍：background: The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]. Function: Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA. Subunit: In pregnancy serum, the proform exists as a disulfide-linked 2:2 heterotetramer with PAPPA, as a disulfide-linked 2:2 heterotetramer with AGT, and as a complex (probably a 2:2:2 heterohexamer) with AGT and C3dg. Subcellular嗜酸性粒细胞颗粒关键碱性蛋白抗体 Location: Bone marrow proteoglycan: Secreted. Note=The proform is secreted. Eosinophil granule major basic protein: Cytoplasmic vesicle, secretory vesicle. Note=The proform is secreted. The mature protein is found in the matrix of the eosinophil's large specific granule (crystalloid core). Tissue Specificity: High levels of the proform in placenta and pregnancy serum; in placenta, localized to X cells of 嗜酸性粒细胞颗粒关键碱性蛋白抗体septa and anchoring villi. Lower levels in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow and colon. Post-translational modifications: Nitrated. Similarity: Contains 1 C-type lectin domain. Gene ID: 5553 Database links: Entrez Gene: 5553 Human Omim: 605601 Human SwissProt: P13727 Human Unigene: 512633 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
嗜酸性粒细胞颗粒关键碱性蛋白抗体研究领域：细胞生物 **学 自然杀伤细胞 **细胞
储存条件：
来源： Rabbit
外观： Lyophilized or Liquid