Notch信号通路Delta样配体1抗体
规格：1mg/1ml
英文名： DLL1
别名： Delta (Drosophila) like 1; Delta; Delta like 1 (Drosophila); Delta like 1; Delta like 1 protein; Delta like protein 1; Delta like protein 1 precursor; Delta, Drosophila, homolog of 1; Delta-like prote
分子量： 76kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human DLL1
交叉反应：Human, Mouse, Rat, Chicken, Cow,
细胞定位：细胞膜
Notch信号通路Delta样配体1抗体产品介绍：background: The LIN-12/Notch family of transmembrane receptors is believed to play a central role in development by regulating cell fate decisions. Notch proteins have been found to be overexpressed or rearranged in human tumors. Ligands for Notch include Jagged, Jagged-2 and Delta. While blocking the differentiation of progenitor cells into the B cell lineage, Delta promotes the emergence of a population of cells with T cell/NK-cell characteristics. Delta is a membrane protein expressed in heart, pancreas, brain and muscle during gastrulation and early organogenesis, and in ***** heart and lung. Function: Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor. Subunit: Interacts with Notch receptors. Subcellular Location: Membrane. Tissue Specificity: Expressed in heart and pancreas, Notch信号通路Delta样配体1抗体with lower expression in brain and muscle and almost no expression in placenta, lung, liver and kidney. Post-translational modifications: Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation. Similarity: Contains 1 DSL domain. Contains 8 EGF-like domains. Database links: Entrez Gene: 28514 Human Entrez Gene: 13388 Mouse Entrez Gene: 84010 Rat Omim: 606582Notch信号通路Delta样配体1抗体 Human SwissProt: O00548 Human SwissProt: Q61483 Mouse SwissProt: P97677 Rat Unigene: 379912 Human Unigene: 4875 Mouse Unigene: 10628 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Notch信号通路Delta样配体1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 干细胞 转录调节因子 **细胞 b-**细胞 表观遗传学
储存条件：
来源： Rabbit
外观： Lyophilized or Liquid