肥大细胞膜抑制性受体Allergin1抗体
规格：1mg/1ml
英文名： Allergin-1
别名： C17orf60; MILR1_HUMAN; Chromosome 17 open reading frame 60.
分子量： 36kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Allergin
交叉反应：Human,
细胞定位：细胞膜
产肥大细胞膜抑制性受体Allergin1抗体品介绍：background: As a major event in type Ⅰ allergic reaction,degranulation of mast cells is triggered by the interaction between specific IgEs and high affinity IgE receptors (FcεRIs) on mast cell membrane,and is followed by the release of a battery of inflammatory mediators,such as histamine,leukotrienes and arachidonic acid,and these inflammatory mediators in turn induce a series of allergic symptoms.Recently,Allergin-1 has been found to be an immunoglobulin-like receptor preferentially expressed on mast cells.The crosslinking of Allergin-1 to FcεRIs on mast cells may inhibit the signal transduction from FcεRIs to intracellular immunoreceptor tyrosine-based inhibitory motif (ITIM),generate ITIM inhibitory signals,which then participate in the regulation of mast cell degranulation,and finally block肥大细胞膜抑制性受体Allergin1抗体 the initiation of allergic inflammation. Function: Immunoglobulin-like receptor which plays an inhibitory role in degranulation of mast cells. Negatively regulates IgE-mediated mast cell activation and suppresses the type I immediate hypersensitivity reaction. Subcellular Location: Cell membrane. Tissue Specificity: Expressed in myeloid cells (dendritic cells, macrophages and neutrophils, weak expression on 肥大细胞膜抑制性受体Allergin1抗体B-cells but not in T-cells or natural killer cells), peripheral blood basophils and mast cells (at protein level). Post-translational modifications: N-glycosylated. Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains. Gene ID: 284021 Database links: Entrez Gene: 284021 Human SwissProt: Q7Z6M3 Human Unigene: 631749 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
肥大细胞膜抑制性受体Allergin1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学
储存条件：
来源： Rabbit
外观： Lyophilized or Liquid