细胞表面**球蛋白样转录因子4抗体
规格：1mg/1ml
英文名： LILRB2
别名： CD85D; CD85 antigen-like family member D; CD85d; CD85d antigen; ILT 4; ILT-4; ILT4; Immunoglobulin like transcript 4; Immunoglobulin-like transcript 4; Leukocyte immunoglobulin like receptor 2; Leukoc
分子量： 21kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human LILRB2
交叉反应：Human,
细胞定位：细胞膜
细胞表面**球蛋白样转录因子4抗体产品介绍：background: Leukocyte immunoglobulin-like receptors (LIRs) are members of the immunoglobulin superfamily of glycoproteins and are predominantly expressed by monocytes, B cells, dendritic cells, natural killer (NK) cells, peripheral blood leukocytes and tissues such as placenta, lung and liver. These receptors all contain a cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM), have an inhibitory function and are type I membrane proteins. When they bind to MHC (or other ligands) and ITIM is tyrosine phosphorylated, protein-tyrosine phosphatases are recruited and an inhibitory signal cascade triggered. ILT-4, also designated LIR-2, MIR-10 or CD85D antigen, competes with CD8A for binding to class I MHC antigens. Function: Receptor for class I MHC antigens. Recognizes a细胞表面**球蛋白样转录因子4抗体 broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. Subcellular Location: Membrane. Tissue Specificity: Expressed on monocytes and B-cells, and at lower levels on dendritic cells. Detected at low levels in natural killer (NK) cells. Post-translational modifications: Phosphorylated on tyrosine细胞表面**球蛋白样转录因子4抗体 residues. Dephosphorylated by PTPN6. Similarity: Contains 4 Ig-like C2-type (immunoglobulin-like) domains. Database links: Entrez Gene: 10288 Human Omim: 604815 Human SwissProt: Q8N423 Human Unigene: 655652 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
细胞表面**球蛋白样转录因子4抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 细胞膜受体 细胞表面分子
储存条件：
来源： Rabbit
外观： Lyophilized or Liquid