沉默调节相关蛋白2抗体
规格：1mg/1ml
英文名： SIRT2
别名： FLJ35621; FLJ37491; NAD dependent deacetylase sirtuin 2; NAD-dependent deacetylase sirtuin-2; Regulatory protein SIR2 homolog 2; Silencing information regulator 2 like; Silent information regulator 2;
分子量： 36kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SIRT2
交叉反应：Human, Mouse, Rat, Dog, Pig, Horse, Rabbit,
细胞定位：细胞浆
沉默调节相关蛋白2抗体产品介绍：background: This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. [provided by RefSeq, Jul 2010] Function: NAD-dependent protein deacetylase, which deacetylates the 'Lys-40' of alpha-tubulin. Involved in沉默调节相关蛋白2抗体 the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton. Subcellular Location: Cytoplasm, cytoskeleton. Colocalizes with microtubules. Tissue Specificity: Widely expressed. Highly expressed in heart, brain and skeletal muscle, while it is weakly expressed in placenta and lung. Down-regulated in many gliomas suggesting that it may act as a tumor suppressor gene in human gliomas possibly沉默调节相关蛋白2抗体 through the regulation of microtubule network. Post-translational modifications: Phosphorylated at the G2/M transition of the cell cycle. Similarity: Belongs to the sirtuin family. Contains 1 deacetylase sirtuin-type domain. Database links: Entrez Gene: 22933 Human Omim: 604480 Human SwissProt: Q8IXJ6 Human Unigene: 466693 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产沉默调节相关蛋白2抗体品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 细胞周期蛋白 转录调节因子 表观遗传学
储存条件：
来源： Rabbit
外观： Lyophilized or Liquid