IL-1相关Ig受体抗体
规格：1mg/1ml
英文名： SIGIRR
别名： Ig IL1 related receptor; MGC110992; SIGIR_HUMAN; SIGIRR; Single Ig IL 1 related receptor; Single Ig IL-1-related receptor; Single Ig IL-1R-related molecule; Single Ig IL1R Related Molecule; Single imm
分子量： 46kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SIGIRR
交叉反应：Human, Mouse, Rat, Pig, Horse,
细胞定位：细胞膜
IL-1相关Ig受体抗体产品介绍：background: Single Ig IL-1-related receptor SIGIRR, also designated single immunoglobulin domain-containing IL-1R-related protein or Toll/interleukin-1 receptor 8 (TIR8), is a member of the interleukin-1 receptor family. SIGIRR acts as a negative regulator of the IL-1R and Toll-like receptor signaling pathways and reduces the recruitment of certain components to the TLR4 receptor. Subsequently, SIGIRR confers resistance to P. aeruginosa corneal infection. SIGIRR can form complexes with IL-1R1, MYD-88, IRAK-1 and TRAF-6 upon IL-1 stimulation and TLR4 after LPS stimulation. It is a single-pass type III membrane protein that is mainly expressed in kidney, lung and gut. Function: Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferesIL-1相关Ig受体抗体 with the heterodimerization of Il1R1 and IL1RAP. Subcellular Location: Membrane. Tissue Specificity: Mainly expressed in epithelial tissues such as kidney, lung and gut. Similarity: Belongs to the interleukin-1 receptor family. Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 TIR domain. Gene ID: 59307 Database links: Entrez Gene: 59307 Human Entrez Gene: 24058 Mouse Entrez Gene: 309106 Rat IL-1相关Ig受体抗体Omim: 605478 Human SwissProt: Q6IA17 Human SwissProt: Q9JLZ8 Mouse SwissProt: Q4V892 Rat Unigene: 501624 Human Unigene: 38017 Mouse Unigene: 16525 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
IL-1相关Ig受体抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 细胞膜受体
储存条件：
来源： Rabbit
外观： Lyophilized or Liquid