胰岛素基因增强结合蛋白1/2抗体
规格：1mg/1ml
英文名： Islet-1+2
别名： Insulin gene enhancer protein ISL 1; Insulin gene enhancer protein ISL-1; Insulin related protein; Isl 1; ISL LIM homeobox 1; ISL1; ISL1 transcription factor LIM homeodomain; ISL1 transcription factor
分子量： 39kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Islet-1/
交叉反应：Human, Mouse, Rat, Cow, Horse, Sheep,
细胞定位：
胰岛素基因增强结合蛋白1/2抗体产品介绍：background: Islet-1 and Islet-2 contain amino-terminal LIM domains and a carboxy-terminal homeodomain and both influence developmental events. Islet-1 influences embryogenesis of the pancreatic islets of Langerhans and neural tube motor neuron differentiation. In developing mouse teeth, Islet-1 mediates patterning of dentition as an activator of Bmp4 expression in incisor (distal) areas of the stomatodeal epithelium. Islet-1 expression defines cardiac progenitor cell populations and is required for normal cardiac development and asymmetry. Islet-2 activity in newly generated motor neurons permits the diversification of visceral and 胰岛素基因增强结合蛋白1/2抗体somatic motor neuron subtypes in the developing spinal cord. Murine Islet-2 specifies retinal ganglion cell (RGC) laterality by repressing an ipsilateral pathfinding program unique to the ventral-temporal crescent (VTC) of RGCs in a Zic2- and EphB1-dependent manner. Function: Binds to one of the cis-acting domain of the insulin gene enhancer. Subcellular Location: Nucleus. Tissue Specificity: Expressed in subsets 胰岛素基因增强结合蛋白1/2抗体of neurons of the adrenal medulla and dorsal root ganglion, inner nuclear and ganglion cell layers in the retina, the pineal and some regions of the brain. Similarity: Contains 1 homeobox DNA-binding domain. Contains 2 LIM zinc-binding domains. Database links: UniProtKB/Swiss-Prot: P61371.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产胰岛素基因增强结合蛋白1/2抗体品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 细胞生物 神经生物学 信号转导 干细胞 细胞类型标志物
储存条件：
来源： Rabbit
外观： Lyophilized or Liquid