泛素样蛋白Sumo2/3抗体
规格：1mg/1ml
英文名： Sumo 2+3
别名： HSMT3; MGC117191; OTTHUMP; OTTHUMP; OTTHUMP; Sentrin 2; Small ubiquitin like modifier 2; Small ubiquitin like modifier protein 3; Small ubiquitin related modifier 2; S
分子量： 10.9+10.5kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Sumo 2+3
交叉反应：Human, Mouse, Rat, Chicken, Cow, Horse, Rabbit, Zebrafish,
细胞定位：细胞核
泛素样蛋白Sumo2/3抗体产品介绍：background: The small ubiquitin-related modifier (SUMO) proteins, which include SUMO-1, SUMO-2 and SUMO-3, belong to the ubiquitin-like protein family. Like ubiquitin, the SUMO proteins are synthesized as precursor proteins that undergo processing before conjugation to target proteins. Also, both utilize the E1, E2, and E3 cascade enzymes for conjugation. However, SUMO and ubiquitin differ with respect to targeting. Ubiquitination predominantly targets proteins for degradation, whereas sumoylation targets proteins to a variety of cellular processing, including nuclear transport, transcriptional regulation, apoptosis and protein stability. The unconjugated SUMO-1, SUMO-2 and SUMO-3 proteins localize to the nuclear membrane, nuclear bodies and cytoplasm, respectively. SUMO-1 utilizes Ubc9 for conjugation to several target proteins, which include IkBa, MDM2, p53, PML and Ran GAP1. SUMO-2 and SUMO-3 contribute to a greater percentage of protein modification than does SUMO-1, and unlike SUMO-1, they can form polymeric chains. In addition, SUMO-3 regulates b-Amyloid generation and may be critical in the onset or progression of Alzheimer’s disease. Function: SUMO proteins, such as Sumo 2 and Sumo 3, post-translationally modify numerous cellular proteins and affect their metabolism and function. However, unlike ubiquitination, which targets proteins for degradation, sumoylation participates in a number of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. Sumo 2 and Sumo 3 are泛素样蛋白Sumo2/3抗体 highly homologous, hence it is very difficult to produce antibodies which distinguish them. Subunit: Homotrimer (Potential). Crystal packing analysis suggests a possible trimeric assembly, of which the biological significance remains to be determined. Interacts with SAE2 and UBE2I. Covalently attached to a number of proteins. Interacts with PELP1. Interacts with USP25; the interaction sumoylates USP25. Interacts with SIMC1, CASP8AP2, RNF111 AND SOBP (via SIM domains). Subcellular Location: Cytoplasmic (SUMO3) and Nuclear (SUMO2) Tissue Specificity: Broadly expressed. Post-translational modifications: Polymeric chains can be formed through Lys-11 cross-linking. Polymeric SUMO2 chains undergo 'Lys-6'-, 泛素样蛋白Sumo2/3抗体'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination by RNF4. Cleavage of precursor form by SENP1 or SENP2 is necessary for function. Similarity: Belongs to the ubiquitin family. SUMO subfamily. Contains 1 ubiquitin-like domain. Database links: UniProtKB/Swiss-Prot: P61956.3 UniProtKB/Swiss-Prot: P55854.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
泛素样蛋白Sumo2/3抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 细胞周期蛋白 泛素
储存条件：
来源： Rabbit
外观： Lyophilized or Liquid
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