锌指蛋白513抗体
规格：1mg/1ml
英文名： ZNF513
别名： FLJ32203; HMFT0656; MGC105911; RP58; Zfp513; Zinc finger protein 513; ZN513_HUMAN; Znf513; Znf513 zinc finger protein 513.
分子量： 58kDa
储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ZNF513
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Sheep,
细胞定位：细胞核
锌指蛋白513抗体产品介绍：background: The protein encoded by this gene is a possible transcriptional regulator involved in retinal development. Defects in this gene can be a cause of autosomal-recessive retinitis pigmentosa. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011] Function: Transcriptional regulator that plays a role in retinal development and maintenance. Subunit: Binds DNA. Can associate with the proximal promoter regions of PAX6 and SP4, and their known targets including ARR3, RHO, OPN1MW2 and OPN1SW. Subcellular Location: Nucleus. Tissue Specificity: In the retina, expressed in the outer and inner nuclear layers, and the ganglion cell layer. DISEASE: Defects in ZNF513 are the cause of retinitis pigmentosa type 58 (RP58) [MIM:613617]. A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination锌指蛋白513抗体 and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 8 C2H2-type zinc fingers. Gene ID: 130557 Database锌指蛋白513抗体 links: Entrez Gene: 130557 Human Entrez Gene: 101023 Mouse Entrez Gene: 313913 Rat Omim: 613598 Human SwissProt: Q8N8E2 Human SwissProt: Q6PD29 Mouse SwissProt: Q5FWU5 Rat Unigene: 515872 Human Unigene: 45033 Mouse Unigene: 15926 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
锌指蛋白513抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学 转录调节因子 锌指蛋白 表观遗传学
储存条件：
来源： Rabbit
外观： Lyophilized or Liquid