T**细胞分化蛋白MAL2抗体
规格：1mg/1ml
英文名： MAL2
别名： MAL 2; MAL proteolipid protein 2; Mal, T cell differentiation protein 2; mal2; MAL2_HUMAN; Protein MAL2.
分子量： 19kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MAL2 (21
交叉反应：Human, Mouse, Rat, Pig, Cow,
细胞定位：细胞浆 细胞膜
T**细胞分化蛋白MAL2抗体产品介绍：background: The MARVEL domain is a 130 amino acid motif that contains four transmembrane helices, both of which have cytoplasmic N- and C-terminal regions. MARVEL domain-containing proteins are thought to participate in tight junction regulation, the biogenesis of vesicular transport carriers and in cholesterol-rich membrane apposition events. MAL2 (mal, T-cell differentiation protein 2) is a 176 amino acid multi-pass membrane protein that is associated with lipid rafts and contains one MARVEL domain. Expressed predominately in liver, kidney and lung, MAL2 functions as a member of the polarized machinery transport system and is required for transcytosis, a transporter pathway used to deliver membrane-bound cargo from perinuclear endosomes to the apical surface in a raft-dependent T**细胞分化蛋白MAL2抗体manner. Differential expression of MAL2 is associated with several cancers, including renal cell carcinoma and childhood leukemia, suggesting a role for MAL2 in tumorigensis. Function: Member of the machinery of polarized transport. Required for the indirect transcytotic route at the step of the egress of the transcytosing cargo from perinuclear endosomes in order for it to travel to the apical surface via a raft-dependent pathway. Subunit: Interacts with TPD52L2. Subcellular Location: Cell membrane. Apical cell membrane. Endomembrane system. Cytoplasm > perinuclear region. Associated with lipid rafts. In polarized epithelial cells, restricted to the apical surface. In hepatocytes, as well as in polarized hepatoma HepG2 cells, found in the canalicular membrane, equivalent to the apical surface, beneath the canalicular actin cytoskeleton. In non-polarized HepG2 cells, distributed to the perinuclear region. Tissue Specificity: Predominantly expressed in kidney, lung, and liver. Also found in thyroid gland, stomach and, at lower levels in testis and small intestine. Similarity: Belongs to the MAL family. Contains 1 MARVEL domain. Gene ID: 114569 Database links: EntrezT**细胞分化蛋白MAL2抗体 Gene: 114569 Human Entrez Gene: 105853 Mouse Entrez Gene: 362911 Rat Omim: 609684 Human SwissProt: Q969L2 Human SwissProt: Q8BI08 Mouse Unigene: 201083 Human Unigene: 410994 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产T**细胞分化蛋白MAL2抗体品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 信号转导 细胞分化 **细胞 新陈代谢
储存条件：
来源： Rabbit
外观： Lyophilized or Liquid