锌指蛋白238抗体
规格：1mg/1ml
英文名： ZNF238
别名： 58 kDa repressor protein; C2H2 171; C2H2171; RP58; TAZ 1; TAZ-1; TAZ1; Transcriptional repressor RP58; Translin associated zinc finger protein 1; Translin-associated zinc finger protein 1; ZBTB18; Zin
分子量： 58kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ZNF238
交叉反应：Human, Mouse, Rat, Chicken, Rabbit,
细胞定位：细胞核
锌指蛋白238抗体产品介绍：background: This gene encodes a C2H2-type zinc finger protein which acts a transcriptional repressor of genes involved in neuronal development. The encoded protein recognizes a specific sequence motif and recruits components of chromatin to target genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013] Function: Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons (By similarity). Specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains 锌指蛋白238抗体the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. May also play a role in the organization of chromosomes in the nucleus. Subcellular Location: Nucleus. Associates with condensed chromatin. Tissue Specificity: Lymphoid tissues, testis, heart, brain, skeletal muscle, and pancreas and, at much lower level, other tissues. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Contains 1 BTB (POZ) domain. Contains 4 C2H2-type zinc fingers. Gene ID: 10472 Database links: Entrez Gene:锌指蛋白238抗体 10472 Human Entrez Gene: 30928 Mouse Entrez Gene: 64619 Rat Omim: 608433 Human SwissProt: Q99592 Human SwissProt: Q9WUK6 Mouse SwissProt: Q9JKY3 Rat Unigene: 69997 Human Unigene: 207206 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产锌指蛋白238抗体品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：转录调节因子 结合蛋白 锌指蛋白 表观遗传学
储存条件：
来源： Rabbit
外观： Lyophilized or Liquid