核糖核苷酸还原酶亚基R2抗体
规格：1mg/1ml
英文名： RRM2
别名： R2; Ribonucleoside-diphosphate reductase subunit M2; Ribonucleotide reductase M2 subunit; Ribonucleotide reductase small chain; Ribonucleotide reductase small subunit; RIR2_HUMAN; RR2; RR2M; RRM2.
分子量： 45kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human RRM2
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞浆
核糖核苷酸还原酶亚基R2抗体产品介绍：background: Ribonucleotide reductase is essential for the production and maintenance of the level of deoxyribonucleoside triphosphates (dNTPs) required for DNA synthesis. It is an enzymatic complex consisting of two nonidentical subunits, R1 and R2, which are inactive separately. R2, the smaller subunit, is localized to the cytoplasm. R2 is the limiting factor of the catalytic activity of the ribonucleotide reductase enzymatic complex. R2 expression is strictly correlated to the S-phase of the cell cycle, whereas R1 remains constant throughout all phases of the cell cycle. While R2 seems to be involved solely in the maintenance of dNTPs for DNA replication, a similar protein, p53R2, has been shown to be responsible for the production of dNTPs in response to DNA damage. Function: Provides the核糖核苷酸还原酶亚基R2抗体 precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling. Subunit: Heterodimer of a large and a small subunit. Subcellular Location: Cytoplasm. Post-translational modifications: Phosphorylation on Ser-20 relieves the inhibitory effect on Wnt signaling. Similarity: Belongs to the ribonucleoside diphosphate 核糖核苷酸还原酶亚基R2抗体reductase small chain family. Database links: Entrez Gene: 6241 Human Omim: 180390 Human SwissProt: P31350 Human Unigene: 226390 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
核糖核苷酸还原酶亚基R2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 细胞周期蛋白 表观遗传学
储存条件：
来源： Rabbit
外观： Lyophilized or Liquid