锌指蛋白801抗体
规格：1mg/1ml
英文名： MAZ
别名： MAZ_HUMAN; Myc-associated zinc finger protein; MAZI; Purine-binding transcription factor; Serum amyloid A-activating factor-1; SAF-1; Transcription factor Zif87; ZF87; Zinc finger protein 801; MAZ; Pu
分子量： 53kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MAZ
交叉反应：Human, Mouse, Rat,
细胞定位：细胞核
锌指蛋白801抗体产品介绍：background: The Myc-associated zinc finger protein MAZ is a transcription factor that participates in both the initiation and termination of transcription of target genes. MAZ functions as a true transcriptional repressor in that it represses transcription independent of the c-Myc promoter. Both MAZ and SP1 bind to the parathyroid hormone (PTH)/ PTH-related peptide receptor promoter, thereby influencing the cell-specific expression of its gene product. MAZ and SP1 also regulate expression from the serotonin 1A receptor gene promoter, suggesting that MAZ may act on a variety of promoters through G-C rich sequences, which serve as binding sites for the SP1 family of transcription factors. Competition between SP1 and MAZ control tissue-specific expression of the PNMT gene. The interaction of MAZ with the transcriptional repressor FAC1 may affect gene regulation in neurodegeneration. MAZ also acts as a growth suppressor protein, in part by affecting the 锌指蛋白801抗体levels of key cell cycle regulatory proteins such as cyclin A and E. Function: May function as a transcription factor with dual roles in transcription initiation and termination. Binds to two sites, ME1a1 and ME1a2, within the MYC promoter having greater affinity for the former. Also binds to multiple G/C-rich sites within the promoter of the Sp1 family of transcription factors. Regulates inflammation-induced expression of serum amyloid A proteins. Subunit: Interacts with BPTF. Subcellular Location: Nucleus (Probable). Note=In brains of Alzheimer disease patients, present in a plaque-like 锌指蛋白801抗体structures. Tissue Specificity: Present in kidney, liver and brain. In the brain, highest levels are found in motor cortex and midfrontal cortex (at protein level). Similarity: Contains 6 C2H2-type zinc fingers. Gene ID: 4150 Database links: Entrez Gene: 4150 Human Entrez Gene: 17188 Mouse Entrez Gene: 691842 Rat Omim: 600999 Human SwissProt: P56270 Human SwissProt: P56671 Mouse Unigene: 23650 Human Unigene: 378964 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
锌指蛋白801抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：
储存条件：
来源： Rabbit
外观： Lyophilized or Liquid