磷酸化蛋白酪氨酸激酶BAP135抗体
规格：1mg/1ml
英文名： phospho-TFII I (Tyr248)
别名： BAP135 (phospho Y248); p-BAP135 (phospho Y248); TFII I (phospho Y248); p-TFII I (phospho Y248); BAP 135; BAP-135; BAP135; Bruton tyrosine kinase associated protein 135; Bruton tyrosine kinase-associat
分子量： 112kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthesised phosphopeptide derived from human
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞核 细胞浆
磷酸化蛋白酪氨酸激酶BAP135抗体产品介绍：background: This gene encodes a phosphoprotein containing six characteristic repeat motifs. The encoded protein binds to the initiator element (Inr) and E-box element in promoters and functions as a regulator of transcription. This locus, along with several other neighboring genes, is deleted in Williams-Beuren syndrome. There are many closely related genes and pseudogenes for this gene on chromosome 7. This gene also has pseudogenes on chromosomes 9, 13, and 21. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2013] Function: Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation. Subcellular Location: Cytoplasm. Nucleus. Colocalizes with BTK in the cytoplasm. 磷酸化蛋白酪氨酸激酶BAP135抗体Tissue Specificity: Ubiquitous. Isoform 1 is strongly expressed in fetal brain, weakly in ***** brain, muscle, and lymphoblasts and is almost undetectable in other ***** tissues, while the other isoforms are equally expressed in all ***** tissues. Post-translational modifications: Transiently phosphorylated on tyrosine residues by BTK in response to B-cell receptor stimulation. Phosphorylation on Tyr-248 and Tyr-398, and perhaps, on Tyr-503 contributes to BTK-mediated transcriptional activation. Sumoylated. DISEASE: Note=GTF2I is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a 磷酸化蛋白酪氨酸激酶BAP135抗体consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of GTF2I may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease. Similarity: Belongs to the TFII-I family. Contains 6 GTF2I-like repeats. Gene ID: 2969 Database links: Entrez Gene: 2969 Human Entrez Gene: 14886 Mouse Entrez Gene: 353256 Rat Omim: 601679 Human SwissProt: P78347 Human SwissProt: Q9ESZ8 Mouse SwissProt: Q5U2Y1 Rat Unigene: 647041 Human Unigene: 261570 Mouse Unigene: 412191 Mouse Unigene: 27575 Rat 磷酸化蛋白酪氨酸激酶BAP135抗体Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 转录调节因子 表观遗传学
储存条件：
来源： Rabbit
外观： Lyophilized or Liquid