肿瘤坏死因子受体超家族成员27抗体
规格：1mg/1ml
英文名： EDA2R
别名： X linked ectodysplasin receptor; Ectodysplasin A2 isoform receptor; Ectodysplasin A2 receptor; EDA-A2 receptor; EDA2R; TNFRSF27; TNR27_HUMAN; Tumor necrosis factor receptor superfamily member 27; X li
分子量： 33kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human EDA2R/TN
交叉反应：Human, Mouse, Rat,
细胞定位：细胞膜
肿瘤坏死因子受体超家族成员27抗体产品介绍：background: The tumor necrosis factor receptor (TNFR) superfamily represents a growing family of type I transmembrane glycoproteins that are involved in various cellular functions, including proliferation, differentiation and programmed cell death (1–3). These proteins share homology for cysteine-rich repeats in the extracellular ligand binding domain and an intracellular death domain (1–3). Members of the TNFR superfamily transmit signals through protein-protein interactions, and these signals can lead to the activation of either the caspase and Jun kinase pathways, which promote cell death, or the NFkB pathway, which results in cell survival (1). The ectodermal dysplasia receptor (EDAR) promotes all three of these pathways and mediates ectodermal differentiation (4). EDAR is encoded by the downless gene and is mutated in ectodermal dysplasia syndromes, which are characterized by impaired hair, teeth and sweat gland development (5). Ectodysplasin A (EDA) is a type II membrane protein that is encoded by the Tabby gene and produces many splice variants, the longest of which, 肿瘤坏死因子受体超家族成员27抗体EDA-A1, serves as the ligand for EDAR (5–7). EDA-A2, which differs from EDA-A1 by the deletion of two amino acids, binds only the X-linked ectodysplasin-A2 receptor (XEDAR) (7). Both EDAR and XEDAR exhibit homology with TROY (8). Function: Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6. Subunit: Associates with TRAF1, TRAF3 and TRAF6. Subcellular Location: Membrane; Single-pass type III membrane protein. 肿瘤坏死因子受体超家族成员27抗体Similarity: Contains 3 TNFR-Cys repeats. Gene ID: 60401 Database links: Entrez Gene: 60401 Human Entrez Gene: 245527 Mouse Entrez Gene: 296872 Rat GenBank: AAQ89953 Human Omim: 300276 Human SwissProt: Q9HAV5 Human SwissProt: Q8BX35 Mouse Unigene: 302017 Human Unigene: 189270 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
肿瘤坏死因子受体超家族成员27抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 干细胞 细胞凋亡 细胞周期蛋白 转录调节因子
储存条件：
来源： Rabbit
外观： Lyophilized or Liquid