内皮细胞分化鞘脂G蛋白偶联受体1抗体
规格：1mg/1ml
英文名： EDG1
别名： CD363; CHEDG1; D1S3362; ECGF1; EDG1; EDG 1; Endothelial differentiation G-protein coupled receptor 1; Endothelial differentiation sphingolipid G protein coupled receptor 1; G protein coupled sphingoli
分子量： 44kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human EDG1/CD3
交叉反应：Human, Mouse, Rat, Dog, Horse,
细胞定位：细胞膜
内皮细胞分化鞘脂G蛋白偶联受体1抗体产品介绍：background: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. This inducible epithelial cell G-protein-coupled receptor may be involved in the processes that regulate the differentiation of endothelial cells. Seems to be coupled to the G(i) subclass of heteromeric G proteins. Function: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. This inducible epithelial cell G-protein-coupled receptor may be involved in the processes that regulate the differentiation of endothelial cells. Seems to be coupled to the G(i) subclass of heteromeric G proteins. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Endothelial cells, and to a lesser extent, in vascular smooth muscle cells,内皮细胞分化鞘脂G蛋白偶联受体1抗体 fibroblasts, melanocytes, and cells of epithelioid origin. Post-translational modifications: S1P-induced endothelial cell migration requires the PKB/AKT1-mediated phosphorylation of the third intracellular loop at the Thr-236 residue. Similarity: Belongs to the G-protein coupled receptor 1 family. Gene ID: 1901 Database links: Entrez Gene: 281135 Cow Entrez Gene: 100050049 Horse Entrez Gene: 1901 Human Entrez Gene: 13609 Mouse Entrez Gene: 29733 Rat Omim: 601974 Human SwissProt: Q5E9P3 Cow SwissProt: P21453 Human SwissProt: 内皮细胞分化鞘脂G蛋白偶联受体1抗体O08530 Mouse SwissProt: P48303 Rat Unigene: 154210 Human Unigene: 982 Mouse Unigene: 109455 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 研究发现，S1P1与VEGF肩并肩相互协作，从而促进血管生长。VEGF是很多不同****的作用靶标。血管新生在很多**是异常的。靶向S1P1和VEGF可能要比只使用VEGF抑制剂更加有效地****；S1P1是一种关键性的血管新生反应性基因。研究人员证实当新的血管网络形成时，由此产生的血液流动激**管内皮细胞表面上的S1P1，并把信号传递到这些细胞内部从而让新形成的血管网内皮细胞分化鞘脂G蛋白偶联受体1抗体络稳定化。因此阻断S1P1可能有助于切断给癌性肿瘤提供资源的血液供应。
产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 细胞凋亡 细胞粘附分子 G蛋白偶联受体 内皮细胞 细胞骨架
储存条件：
来源： Rabbit
外观： Lyophilized or Liquid